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Interactive Analytics and Visualization for Data Driven Calculation of Individualized COPD Risk
Linköping University, Department of Computer and Information Science, Human-Centered systems.
2018 (English)Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
Abstract [en]

Chronic obstructive pulmonary disease (COPD) is a high mortality disease, second to stroke and ischemic heart disease. This non-curable disease progressively exacerbates, leading to high personal and societal economic impact, reduced quality of life and often death. General treatment plans for COPD risk mistreating the individuals’ condition. To be effective, the treatment should be individualized following the practices of precision medicine. The aim of this thesis was to develop a data driven algorithm and system with visualization to assess individual COPD risk. With MRI body composition profile measurements, it is possible to accurately assess propensity of a multitude of metabolic conditions, such as coronary heart disease and type 2 diabetes.  The algorithm and system has been developed using Wolfram Language and R within the Wolfram Mathematica framework. The algorithm calculates individualized virtual control groups metabolically similar to the patient’s body composition and spirometric profile. Using UK Biobank data, our tool was used to assess patient COPD propensity using an individual-specific virtual control group with AUROC 0.778 (female) and 0.758 (men). Additionally, the tool was used to identify new body composition profiles related to COPD and associated comorbid conditions.

Place, publisher, year, edition, pages
2018. , p. 87
Keywords [en]
COPD, Visualization, Big Data, Virtual Control Group
National Category
Pharmaceutical Biotechnology Human Computer Interaction
Identifiers
URN: urn:nbn:se:liu:diva-151925ISRN: LIU-IDA/LITH-EX-A--18/026--SEOAI: oai:DiVA.org:liu-151925DiVA, id: diva2:1254802
External cooperation
AMRA Medical; Wolfram Mathcore
Subject / course
Biotechnology
Presentation
2018-06-13, Alan Turing, Linköping, 11:11 (Swedish)
Supervisors
Examiners
Available from: 2018-10-11 Created: 2018-10-10 Last updated: 2018-10-11Bibliographically approved

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Interactive Visualization COPD Emil Arkstål(5229 kB)37 downloads
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CiteExportLink to record
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Citation style
  • apa
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Output format
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