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An observational study on the sub-acute effects of mephedrone on mood, cognition, sleep and physical problems in regular mephedrone users
Linköping University, Department of Clinical and Experimental Medicine, Center for Social and Affective Neuroscience. Linköping University, Faculty of Medicine and Health Sciences. Department of Psychology, University of Sussex, Brighton, UK.
Department of Psychology, University of Sussex, Brighton, UK.
Department of Psychology, University of Sussex, Brighton, UK; Norwegian Center for Addiction Research, University of Oslo, Oslo, Norway.
2018 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 235, no 9, p. 2609-2618Article in journal (Refereed) Published
Abstract [en]

Mephedrone (4-methylmethcathinone; 4-MMC) is a novel recreational drug similar to methylenedioxymethamphetamine (MDMA) and amphetamine. Several adverse effects have been reported, but little is known about its sub-acute effects. To study sub-acute effects of mephedrone over a period of 9 days. Recreational mephedrone users were recruited and followed over a time period of 9 days. It was recorded whether participants consumed mephedrone or not within the period of testing; those who did were compared to those who did not. Forty-six regular mephedrone users (22 males, 24 females) participated, 21 participants voluntarily opted to consume mephedrone 1-3 days after baseline and 25 opted to abstain. Participants were assessed at baseline on a multitude of measures and provided daily reports on cognition, sleep, mood, physical problems, mephedrone cravings and substance use on each subsequent day of the study. The study controlled for psychopathology, sleep, past and current substance use, impulsivity and demographics. Those who consumed mephedrone reported persistent negative mood, physical problems and fatigue, compared to those who did not-after controlling for baseline group differences in sleep and subsequent alcohol and cannabis use. The results provide the first prospective evidence of the duration and extent of specific undesirable sub-acute effects of mephedrone in regular recreational users and indicate sub-acute effects of mephedrone on mood, fatigue and physical symptoms.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 235, no 9, p. 2609-2618
Keywords [en]
Mephedrone; Cathinone; Sub-acute effects; Mood; Cognition; Sleep; Physical problems
National Category
Substance Abuse
Identifiers
URN: urn:nbn:se:liu:diva-151497DOI: 10.1007/s00213-018-4953-1ISI: 000443430700009PubMedID: 29946859Scopus ID: 2-s2.0-85049117299OAI: oai:DiVA.org:liu-151497DiVA, id: diva2:1250641
Available from: 2018-09-24 Created: 2018-09-24 Last updated: 2018-10-19Bibliographically approved

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