Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review andmeta-analysis of randomized clinical trials
Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA.
Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA USA; Baim Inst Clin Res, Boston, MA USA.
FACT, Boston, MA USA; Univ Paris Diderot, Hop Bichat, AP HP, Paris, France; INSERM, Paris, France.
Baim Inst Clin Res, Boston, MA USA; Boston Univ, Sch Publ Hlth, Dept Biostat, Crosstown Ctr, Boston, MA USA.
Show others and affiliations
2018 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 39, no 19, p. 1726-+Article, review/survey (Refereed) Published
Abstract [en]

Aims: Of patients with atrial fibrillation (AF), approximately 10% undergo percutaneous coronary intervention (PCI). We studied the safety and efficacy of dual vs. triple antithrombotic therapy (DAT vs. TAT) in this population.

Methods and results: A systematic review and meta-analysis was conducted using PubMed, Embase, EBSCO, Cochrane database of systematic reviews, Web of Science, and relevant meeting abstracts for Phase 3, randomized trials that compared DAT vs. TAT in patients with AF following PCI. Four trials including 5317 patients were included, of whom 3039 (57%) received DAT. Compared with the TAT arm, Thrombolysis in Myocardial Infarction (TIMI) major or minor bleeding showed a reduction by 47% in the DAT arm [4.3% vs. 9.0%; hazard ratio (HR) 0.53, 95% credible interval (CrI) 0.36–0.85, I2 = 42.9%]. In addition, there was no difference in the trial-defined major adverse cardiac events (MACE) (10.4% vs. 10.0%, HR 0.85, 95% CrI 0.48–1.29, I2 = 58.4%), or in individual outcomes of all-cause mortality, cardiac death, myocardial infarction, stent thrombosis, or stroke between the two arms.

Conclusion: Compared with TAT, DAT shows a reduction in TIMI major or minor bleeding by 47% with comparable outcomes of MACE. Our findings support the concept that DAT may be a better option than TAT in many patients with AF following PCI.

Place, publisher, year, edition, pages
2018. Vol. 39, no 19, p. 1726-+
Keywords [en]
Atrial fibrillation, Antithrombotic therapy, Percutaneous coronary intervention, Dual therapy, Triple therapy
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:uu:diva-359375DOI: 10.1093/eurheartj/ehy162ISI: 000432687200015PubMedID: 29668889OAI: oai:DiVA.org:uu-359375DiVA, id: diva2:1248609
Available from: 2018-09-17 Created: 2018-09-17 Last updated: 2018-09-17Bibliographically approved

Open Access in DiVA

fulltext(436 kB)37 downloads
File information
File name FULLTEXT01.pdfFile size 436 kBChecksum SHA-512
20a5bdf0d4370233bc88d529b0ce679643bfe00efd15ac12733e5382985fb5c06d1aaeb9d5ec667695746e36476f996285c87622e914083adba7bf70425a178f
Type fulltextMimetype application/pdf

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Oldgren, Jonas
By organisation
CardiologyUCR-Uppsala Clinical Research Center
In the same journal
European Heart Journal
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar
Total: 37 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 21 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf