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A hybrid approach to predict the relationship between tablet tensile strength and compaction pressure using analytical powder compression
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaci.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Farmaceutiska fakulteten, Institutionen för farmaci.
2018 (engelsk)Inngår i: European journal of pharmaceutics and biopharmaceutics, ISSN 0939-6411, E-ISSN 1873-3441, Vol. 125, s. 28-37Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The objective was to present a hybrid approach to predict the strength-pressure relationship (SPR) of tablets using common compression parameters and a single measurement of tablet tensile strength. Experimental SPR were derived for six pharmaceutical powders with brittle and ductile properties and compared to predicted SPR based on a three-stage approach. The prediction was based on the Kawakita b(-1) parameter and the in-die Heckel yield stress, an estimate of maximal tensile strength, and a parameter proportionality factor alpha. Three values of alpha were used to investigate the influence of the parameter on the SPR. The experimental SPR could satisfactorily be described by the three stage model, however for sodium bicarbonate the tensile strength plateau could not be observed experimentally. The shape of the predicted SPR was to a minor extent influenced by the Kawakita b(-1) but the width of the linear region was highly influenced by alpha. An increased alpha increased the width of the linear region and thus also the maximal predicted tablet tensile strength. Furthermore, the correspondence between experimental and predicted SPR was influenced by the alpha value and satisfactory predictions were in general obtained for alpha = 4.1 indicating the predictive potential of the hybrid approach.

sted, utgiver, år, opplag, sider
ELSEVIER SCIENCE BV , 2018. Vol. 125, s. 28-37
Emneord [en]
Prediction, Compression, Compaction, Tablet tensile strength, Yield pressure
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-352700DOI: 10.1016/j.ejpb.2017.12.011ISI: 000429398100004PubMedID: 29277725OAI: oai:DiVA.org:uu-352700DiVA, id: diva2:1215557
Tilgjengelig fra: 2018-06-08 Laget: 2018-06-08 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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