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CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells
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Antal upphovsmän: 152018 (Engelska)Ingår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 9, artikel-id 486Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.

Ort, förlag, år, upplaga, sidor
2018. Vol. 9, artikel-id 486
Nyckelord [en]
natural killer cells, CD161, pro-inflammatory cytokines, cytomegalovirus, human immunodeficiency virus, inflammatory bowel diseases
Nationell ämneskategori
Immunologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:su:diva-155949DOI: 10.3389/fimmu.2018.00486ISI: 000429466400001PubMedID: 29686665OAI: oai:DiVA.org:su-155949DiVA, id: diva2:1209418
Tillgänglig från: 2018-05-23 Skapad: 2018-05-23 Senast uppdaterad: 2018-05-23Bibliografiskt granskad

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Av författaren/redaktören
Björkander, SophiaSverremark-Ekström, Eva
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Institutionen för molekylär biovetenskap, Wenner-Grens institut
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Frontiers in Immunology
Immunologi inom det medicinska området

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