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Molecular design of radiocopper-labelled Affibody molecules
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. (Vladimir Tolmachev)ORCID iD: 0000-0002-6122-1734
Turku PET Centre, University of Turku, Turku, Finland; MediCity Research Laboratory, University of Turku, Turku, Finland; Department of Oncology and Radiotherapy, Turku University Hospital, Turku, Finland.
Turku PET Centre, University of Turku, Turku, Finland; Turku PET Centre, Åbo Akademi University, Turku, Finland.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology, Medical Radiation Science. (Vladimir Tolmachev)
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, no 1, article id 6542Article in journal (Refereed) Published
Abstract [en]

Cu-CB-TE2A-GEEE-ZHER2:342 was 16 ± 6%ID/g and tumor-to-blood ratio was 181 ± 52. In conclusion, a combination of the cross-bridged CB-TE2A chelator and Gly-Glu-Glu-Glu spacer is preferable for radiocopper labelling of Affibody molecules and, possibly, other scaffold proteins having high renal re-absorption.

Place, publisher, year, edition, pages
2018. Vol. 8, no 1, article id 6542
National Category
Cancer and Oncology Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-349813DOI: 10.1038/s41598-018-24785-2ISI: 000430795000041PubMedID: 29695813OAI: oai:DiVA.org:uu-349813DiVA, id: diva2:1202882
Funder
Swedish Cancer Society, CAN 2015/350Swedish Research Council, 2015-02353Swedish Research Council, 2015-02509Swedish Research Council, 2013-5135Swedish Cancer Society, 2014/474
Note

Vladimir Tolmachev and Tove J. Grönroos contributed equally to this work.

Available from: 2018-05-02 Created: 2018-05-02 Last updated: 2018-06-26Bibliographically approved

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