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ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease
Swedish Univ Agr Sci, Dept Clin Sci, SE-75007 Uppsala, Sweden..
Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, CMM, L8 01, SE-17176 Stockholm, Sweden.;Uppsala Univ, Dept Med Sci, Sci Life Lab, Uppsala, Sweden..
KTH, School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH), Protein Science, Affinity Proteomics. KTH, Centres, Science for Life Laboratory, SciLifeLab.
Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, CMM, L8 01, SE-17176 Stockholm, Sweden..
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2018 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 8, article id 4852Article in journal (Refereed) Published
Abstract [en]

Dogs can spontaneously develop complex systemic autoimmune disorders, with similarities to human autoimmune disease. Autoantibodies directed at self-antigens are a key feature of these autoimmune diseases. Here we report the identification of interleukin enhancer-binding factors 2 and 3 (ILF2 and ILF3) as autoantigens in canine immune-mediated rheumatic disease. The ILF2 autoantibodies were discovered in a small, selected canine cohort through the use of human protein arrays; a method not previously described in dogs. Subsequently, ILF3 autoantibodies were also identified in the same cohort. The results were validated with an independent method in a larger cohort of dogs. ILF2 and ILF3 autoantibodies were found exclusively, and at a high frequency, in dogs that showed a speckled pattern of antinuclear antibodies on immunofluorescence. ILF2 and ILF3 autoantibodies were also found at low frequency in human patients with SLE and Sjogren's syndrome. These autoantibodies have the potential to be used as diagnostic biomarkers for canine, and possibly also human, autoimmune disease.

Place, publisher, year, edition, pages
NATURE PUBLISHING GROUP , 2018. Vol. 8, article id 4852
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:kth:diva-225717DOI: 10.1038/s41598-018-23034-wISI: 000427688100045PubMedID: 29556082Scopus ID: 2-s2.0-85044196918OAI: oai:DiVA.org:kth-225717DiVA, id: diva2:1196622
Funder
Swedish Research CouncilSwedish Foundation for Strategic Research , 2011-1404Ragnar Söderbergs stiftelseNovo NordiskSwedish Rheumatism Association
Note

QC 20180410

Available from: 2018-04-10 Created: 2018-04-10 Last updated: 2019-08-20Bibliographically approved

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