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Depressed serum IgM levels in SLE are restricted to defined subgroups
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Med, Rheumatol Unit, Stockholm, Sweden..
Karolinska Univ Hosp, Karolinska Inst, Dept Clin Immunol & Transfus Med, Unit Clin Immunol, Stockholm, Sweden..
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2017 (Engelska)Ingår i: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 183, s. 304-315Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls. Strikingly, an autoreactivity profile defined by IgG anti-Ro/La was associated with reduced levels of specific natural IgM targeting phosphoiylcholine (PC) antigens and malondialdehyde (MDA) modified-protein, as well as total IgM, while no differences were detected in SLE patients with an autoreactivity profile defined by anti-cardiolipin/beta(2)glycoprotein-I. We also observed an association of reduced IgM levels with the HEA-DRB1*03 allelic variant among SLE patients and controls. Associations of low IgM anti-PC with cardiovascular disease were primarily found in patients without antiphospholipid antibodies. These studies further highlight the clinical relevance of depressed IgM. Our results suggest that low IgM levels in SLE patients reflect immunological and genetic differences between SLE subgroups.

Ort, förlag, år, upplaga, sidor
2017. Vol. 183, s. 304-315
Nyckelord [en]
SLE, Natural IgM, Sjogren's syndrome, Antiphospholipid syndrome, IgM anti-PC, IgM anti-MDA, IgM anti-CWPS, SS, APS, Autoantibodies
Nationell ämneskategori
Reumatologi och inflammation
Identifikatorer
URN: urn:nbn:se:uu:diva-341665DOI: 10.1016/j.clim.2017.09.013ISI: 000414888600042PubMedID: 28919518OAI: oai:DiVA.org:uu-341665DiVA, id: diva2:1182636
Forskningsfinansiär
Vetenskapsrådet, E0395401 201303624Åke Wibergs Stiftelse, M16-0060Magnus Bergvalls Stiftelse, 2014-00149 2015-00987Hjärt-Lungfonden, 20140436Stockholms läns landsting, 1311-1406Stiftelsen Konung Gustaf V:s Jubileumsfond, FAI2015-0187 FAI2014-0005Reumatikerförbundet, R-639601Tillgänglig från: 2018-02-14 Skapad: 2018-02-14 Senast uppdaterad: 2018-02-27Bibliografiskt granskad

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Rönnelid, Johan
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