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Influence of hydrocarbon oil structure on adjuvanticity and autoimmunity
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Vaskulärbiologi. Karolinska Inst, Div Med Inflammat Res, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden. (Elisabetta Dejana)ORCID-id: 0000-0002-1570-7813
Karolinska Inst, Div Med Inflammat Res, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden..
Karolinska Inst, Div Med Inflammat Res, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden..
Karolinska Inst, Div Med Inflammat Res, Dept Med Biochem & Biophys, SE-17177 Stockholm, Sweden..
2017 (engelsk)Inngår i: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 7, artikkel-id 14998Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mineral oils are extensively used in our daily life, in food, cosmetics, biomedicine, vaccines and in different industrial applications. However, exposure to these mineral oils has been associated with immune adjuvant effects and the development of autoimmune diseases. Here we investigate the structural impacts of the hydrocarbon oil molecules on their adjuvanticity and autoimmunity. First, we showed that hydrocarbon oil molecules with small atomic differences could result in experimental arthritis in DA rats differing in disease severity, incidence, weight change and serum levels of acute phase proteins. Injection of these hydrocarbon oils resulted in the activation, proliferation and elevated expression of Th1 and especially Th17 cytokines by the T cells, which correlate with the arthritogenicity of the T cells. Furthermore, the more arthritogenic hydrocarbon oils resulted in an increased production of autoantibodies against cartilage joint specific, triple-helical type II collagen epitopes. When injected together with ovalbumin, the more arthritogenic hydrocarbon oils resulted in an increased production of alpha beta T cell-dependent anti-ovalbumin antibodies. This study shows the arthritogenicity of hydrocarbon oils is associated with their adjuvant properties with implications to not only arthritis research but also other diseases and medical applications such as vaccines in which oil adjuvants are involved.

sted, utgiver, år, opplag, sider
2017. Vol. 7, artikkel-id 14998
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URN: urn:nbn:se:uu:diva-340901DOI: 10.1038/s41598-017-15096-zISI: 000414643000001PubMedID: 29118363OAI: oai:DiVA.org:uu-340901DiVA, id: diva2:1180789
Forskningsfinansiär
Knut and Alice Wallenberg FoundationSwedish Rheumatism AssociationSwedish Society for Medical Research (SSMF)Swedish Foundation for Strategic Research EU, FP7, Seventh Framework Programme, HEALTH-F4-2010-241504Tilgjengelig fra: 2018-02-06 Laget: 2018-02-06 Sist oppdatert: 2018-02-06bibliografisk kontrollert

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