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Long-term Exposure to Ambient Air Pollution and Incidence of Brain Tumor: the European Study of Cohorts for Air Pollution Effects (ESCAPE).
Vise andre og tillknytning
2017 (engelsk)Inngår i: Neuro-Oncology, ISSN 1522-8517, E-ISSN 1523-5866Artikkel i tidsskrift (Fagfellevurdert) Epub ahead of print
Abstract [en]

Background: Epidemiological evidence on the association between ambient air pollution and brain tumor risk is sparse and inconsistent.

Methods: In 12 cohorts from six European countries, individual estimates of annual mean air pollution levels at the baseline residence were estimated by standardized land-use regression models developed within the ESCAPE and TRANSPHORM projects: particulate matter (PM) ≤ 2.5, ≤ 10, and 2.5-10 μm in diameter (PM2.5, PM10, and PMcoarse), PM2.5 absorbance, nitrogen oxides (NO2 and NOx) and elemental composition of PM. We estimated cohort-specific associations of air pollutant concentrations and traffic intensity with total, malignant and nonmalignant brain tumor, in separate Cox regression models, adjusting for risk factors, and pooled cohort-specific estimates using random-effects meta-analyses.

Results: Of 282,194 subjects from 12 cohorts, 466 developed malignant brain tumors during 12 years of follow-up. Six of the cohorts had also data on nonmalignant brain tumor, where among 106,786 subjects, 366 developed brain tumor: 176 nonmalignant and 190 malignant. We found a positive, statistically non-significant association between malignant brain tumor and PM2.5 absorbance (Hazard Ratio and 95% Confidence Interval: 1.67; 0.89-3.14 per 10 -5/m 3), and weak positive or null associations with the other pollutants. Hazard ratio for PM2.5 absorbance (1.01; 0.38-2.71 per 10 -5/m 3) and all other pollutants were lower for nonmalignant than for malignant brain tumors.

Conclusion: We found suggestive evidence of an association between long-term exposure to PM2.5 absorbance indicating traffic-related air pollution and malignant brain tumors, and no association with overall or nonmalignant brain tumors.

sted, utgiver, år, opplag, sider
2017.
Emneord [en]
air pollution, brain cancer, brain tumor, traffic
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-140538DOI: 10.1093/neuonc/nox163PubMedID: 29016987OAI: oai:DiVA.org:umu-140538DiVA: diva2:1149038
Tilgjengelig fra: 2017-10-13 Laget: 2017-10-13 Sist oppdatert: 2017-10-13

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Sommar, Johan NForsberg, BertilOlsson, David
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