Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Voxel-based morphometry multi-center mega-analysis of brain structure in social anxiety disorder
Vise andre og tillknytning
2017 (engelsk)Inngår i: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 16, s. 678-688Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Social anxiety disorder (SAD) is a prevalent and disabling mental disorder, associated with significant psychiatric comorbidity. Previous research on structural brain alterations associated with SAD has yielded inconsistent results concerning the direction of the changes in graymatter (GM) in various brain regions, as well as on the relationship between brain structure and SAD-symptomatology. These heterogeneous findings are possibly due to limited sample sizes. Multisite imaging offers new opportunities to investigate SAD-related alterations in brain structure in larger samples. An international multi-center mega-analysis on the largest database of SAD structural T1-weighted 3T MRI scans to date was performed to compare GM volume of SAD-patients (n = 174) and healthy control (HC)-participants (n = 213) using voxel-based morphometry. A hypothesis-driven region of interest (ROI) approach was used, focusing on the basal ganglia, the amygdala-hippocampal complex, the prefrontal cortex, and the parietal cortex. SAD-patients had larger GM volume in the dorsal striatum when compared to HC-participants. This increase correlated positively with the severity of self-reported social anxiety symptoms. No SAD-related differences in GM volume were present in the other ROIs. Thereby, the results of this mega-analysis suggest a role for the dorsal striatum in SAD, but previously reported SAD-related changes in GM in the amygdala, hippocampus, precuneus, prefrontal cortex and parietal regions were not replicated. Our findings emphasize the importance of large sample imaging studies and the need for meta-analyses like those performed by the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 16, s. 678-688
Emneord [en]
Social anxiety disorder, Structural MRI, Voxel-based morphometry, Gray matter, Mega-analysis, Striatum
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-138294DOI: 10.1016/j.nicl.2017.08.001ISI: 000413235100071OAI: oai:DiVA.org:umu-138294DiVA, id: diva2:1133862
Tilgjengelig fra: 2017-08-17 Laget: 2017-08-17 Sist oppdatert: 2018-06-09bibliografisk kontrollert

Open Access i DiVA

fulltext(1084 kB)84 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1084 kBChecksum SHA-512
ba6b4ead0706cc27a8195ca3d1351e2f9db71c4d595d95b62920ec992f6063286c1b34786c46ef5d7649e62eacd5ccf7577906a78c6bf1370f90dbc21253da35
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Boraxbekk, Carl-Johan
Av organisasjonen
I samme tidsskrift
NeuroImage: Clinical

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 84 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 425 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf