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Temporal trend of autonomic nerve function and HSP27, MIF and PAI-1 in type 1 diabetes
Umeå University, Faculty of Medicine, Department of Public Health and Clinical Medicine, Family Medicine.
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2017 (English)In: Journal of clinical and translational endocrinology, ISSN 2214-6237, Vol. 8, p. 15-21Article in journal (Refereed) Published
Abstract [en]

Aim: Diabetes mellitus type 1 (T1D) has numerous complications including autonomic neuropathy, i.e. dysfunction of the autonomous nervous system. This study focuses on Heat Shock Protein 27 (HSP27), Macrophage Migration Inhibitory Factor (MIF), Plasminogen Activator Inhibitor-1 (PAI-1) and HbA1c and their possible roles in effects of diabetes on the autonomic nervous system.

Methods: Patients with T1D (n = 32, 41% women) were recruited in 1985 and followed up on four occasions (1989, 1993, 1998, and 2005). Autonomic function was tested using expiration/inspiration (E/I-ratio). Blood samples, i.e. HSP27 (last three occasions), MIF, PAI-1 (last two occasions) and HbA1c (five occasions), were analyzed.

Results: Autonomic nerve function deteriorated over time during the 20-year-period, but levels of HSP27, MIF, and PAI-1 were not associated with cardiovascular autonomic neuropathy. MIF and PAI-1 were lower in T1D than in healthy controls in 2005. Increased HbA1c correlated with a decrease in E/I-ratio.

Conclusions: Neither the neuroprotective substance HSP27 nor the inflammatory substances, MIF and PAI-1 were associated with measures of cardiovascular autonomic nerve function, but a deterioration of such function was observed in relation to increasing HbA1c in T1D during a 20-year follow-up period. Improved glucose control might be associated with protection against autonomic neuropathy in T1D.

Place, publisher, year, edition, pages
2017. Vol. 8, p. 15-21
Keywords [en]
Type 1 diabetes mellitus, Diabetic autonomic neuropathy, Heat-Shock Protein 27, Macrophage gration Inhibition Factors, PAI-1
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:umu:diva-138043DOI: 10.1016/j.jcte.2017.03.001ISI: 000405747800003OAI: oai:DiVA.org:umu-138043DiVA, id: diva2:1131312
Available from: 2017-08-14 Created: 2017-08-14 Last updated: 2019-05-21Bibliographically approved

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