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Neutrophil alterations in pregnancy-associated malaria and induction of neutrophil chemotaxis by Plasmodium falciparum
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Vise andre og tillknytning
Rekke forfattare: 122017 (engelsk)Inngår i: Parasite immunology (Print), ISSN 0141-9838, E-ISSN 1365-3024, Vol. 39, nr 6, artikkel-id UNSP e12433Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Pregnancy-associated malaria (PAM) is a severe form of the disease caused by sequestration of Plasmodium falciparum-infected red blood cells (iRBCs) in the developing placenta. Pathogenesis of PAM is partially based on immunopathology, with frequent monocyte infiltration into the placenta. Neutrophils are abundant blood cells that are essential for immune defence but may also cause inflammatory pathology. Their role in PAM remains unclear. We analysed neutrophil alterations in the context of PAM to better understand their contribution to disease development. Pregnant women exposed to Plasmodium falciparum had decreased numbers of circulating neutrophils. Placental-like BeWo cells stimulated with malaria parasites produced the neutrophil chemoattractant IL-8 and recruited neutrophils in a trans-well assay. Finally, immunostaining of a PAM placenta confirmed neutrophil accumulation in the intervillous space. Our data indicate neutrophils may play a role in placental malaria and should be more closely examined as an etiological agent in the pathophysiology of disease.

sted, utgiver, år, opplag, sider
2017. Vol. 39, nr 6, artikkel-id UNSP e12433
Emneord [en]
IL-8, neutrophils, placenta, Plasmodium falciparum, pregnancy
HSV kategori
Identifikatorer
URN: urn:nbn:se:su:diva-145252DOI: 10.1111/pim.12433ISI: 000403537900006OAI: oai:DiVA.org:su-145252DiVA, id: diva2:1128648
Tilgjengelig fra: 2017-07-27 Laget: 2017-07-27 Sist oppdatert: 2017-07-27bibliografisk kontrollert

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