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From pituitary adenoma to pituitary neuroendocrine tumor (PitNET): an International Pituitary Pathology Club proposal
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Immunology, Genetics and Pathology.ORCID iD: 0000-0001-7376-7331
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2017 (English)In: Endocrine-Related Cancer, ISSN 1351-0088, E-ISSN 1479-6821, Vol. 24, no 4, p. C5-C8Article in journal (Refereed) Published
Abstract [en]

The classification of neoplasms of adenohypophysial cells is misleading because of the simplistic distinction between adenoma and carcinoma, based solely on metastatic spread and the poor reproducibility and predictive value of the definition of atypical adenomas based on the detection of mitoses or expression of Ki-67 or p53. In addition, the current classification of neoplasms of the anterior pituitary does not accurately reflect the clinical spectrum of behavior. Invasion and regrowth of proliferative lesions and persistence of hormone hypersecretion cause significant morbidity and mortality. We propose a new terminology, pituitary neuroendocrine tumor (PitNET), which is consistent with that used for other neuroendocrine neoplasms and which recognizes the highly variable impact of these tumors on patients.

Place, publisher, year, edition, pages
2017. Vol. 24, no 4, p. C5-C8
Keywords [en]
nomenclature, pituitary tumors
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Clinical Laboratory Medicine
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URN: urn:nbn:se:uu:diva-318372DOI: 10.1530/ERC-17-0004ISI: 000395905600001PubMedID: 28264912OAI: oai:DiVA.org:uu-318372DiVA, id: diva2:1084391
Available from: 2017-03-24 Created: 2017-03-24 Last updated: 2017-11-29Bibliographically approved

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