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Circulating YKL-40 in patients with essential thrombocythemia and polycythemia vera treated with the novel histone deacetylase inhibitor vorinostat
Dept Hematol, Roskilde Univ Hosp, Roskilde, Denmark..
Dept Hematol, Roskilde Univ Hosp, Roskilde, Denmark..
Dept Haematol, Queen Univ Belfast Antrim, Belfast, North Ireland.
Dept Haematol, NHS Fdn Trust, London, England.
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2014 (English)In: Leukemia research: a Forum for Studies on Leukemia and Normal Hemopoiesis, ISSN 0145-2126, E-ISSN 1873-5835, Vol. 38, no 7, p. 816-821Article in journal (Refereed) Published
Abstract [en]

YKL-40 regulates vascular endothelial growth factors and induces tumor proliferation. We investigated YKL-40 before and after treatment with vorinostat in 31 polycythemia vera (PV) and 16 essential thrombocythemia (ET) patients. Baseline PV patient levels were 2 times higher than in healthy controls (P<0.0001) and 1.7 times higher than in ET (P = 0.02). A significant correlation between YKL-40 at baseline and neutrophils, CRP, LDH, JAK2V617F and platelets in PV patients was observed, as well as a significantly greater reduction of YKL-40 levels in PV patients responding to therapy. YKL-40 might be a novel marker of disease burden and progression in myeloproliferative neoplasms.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 38, no 7, p. 816-821
Keywords [en]
Yk1-40, Essential thrombocythemia, Polycythemia vera, Vorinostat, Phase II study
National Category
Cancer and Oncology Hematology
Identifiers
URN: urn:nbn:se:oru:diva-56308DOI: 10.1016/j.leukres.2014.04.002ISI: 000339339400015PubMedID: 24836761OAI: oai:DiVA.org:oru-56308DiVA, id: diva2:1081361
Available from: 2017-03-14 Created: 2017-03-14 Last updated: 2018-09-06Bibliographically approved

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Ahlstrand, ErikGronbaek, Kirsten
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