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Measuring Uptake and Elimination of Nitrogen in Humans at Different Ambient Pressures
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.ORCID iD: 0000-0001-6361-8965
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
KTH, School of Technology and Health (STH), Basic Science and Biomedicine, Environmental Physiology. KTH, School of Technology and Health (STH), Centres, Swedish Aerospace Physiology Centre, SAPC.
2016 (English)In: Aerospace Medicine and Human Performance, ISSN 2375-6314, Vol. 87, no 12, p. 1045-1050Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To measure nitrogen (N-2) wash-out and uptake requires elaborate set-ups, especially when doing the measurements at increased or decreased ambient pressure. Here we present a transportable device for quantifying N-2 turnover in humans which can be used at different ambient pressures. METHODS: A modified close-circuit electronic rebreather was used to assess N-2 turnover. Changes in N-2 volume within the rebreathing circuit, reflecting N-2 uptake or washout, were derived from the continuously monitored total system volume and the calculated volumes of oxygen and water vapor. The calculation of continuous N-2 volume curves was performed off-line using dedicated computer software. RESULTS: Four subjects participated in the proof-of-concept tests. At steady state, the drift in calculated N-2 volume in the rebreathing circuit over a 1-h duration was minimal. Three of the subjects participated in additional N-2 steady-state measurements where 1019 mL (BTPD) of N-2 was injected into the rebreathing circuit over 20 min and the measured volume increase was 1006 +/- 32 mL. Lastly, N-2 elimination was assessed during decompression to 0.5 atm and while breathing hyperoxic gas. N-2 uptake was measured during compression to 1.8 atm. The elimination and uptake curves were deemed to be realistic. DISCUSSION: A method for assessing N-2 turnover in humans has been developed and a first evaluation has been performed. It is easy to work with operationally and can be used at different ambient pressures. More research is needed in order to further validate it as a method for assessing N-2 turnover in humans.

Place, publisher, year, edition, pages
AEROSPACE MEDICAL ASSOC , 2016. Vol. 87, no 12, p. 1045-1050
Keywords [en]
decompression, nitrogen elimination, pressure, diving
National Category
Physiology
Identifiers
URN: urn:nbn:se:kth:diva-199515ISI: 000389010500011Scopus ID: 2-s2.0-85020036326OAI: oai:DiVA.org:kth-199515DiVA, id: diva2:1066038
Note

QC 20170117

Available from: 2017-01-17 Created: 2017-01-09 Last updated: 2018-09-19Bibliographically approved

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Sundblad, PatrikSiebenmann, ChristophGennser, Mikael
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