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A simple polyol-free synthesis route to Gd 2O 3 nanoparticles for MRI applications: An experimental and theoretical study
Vise andre og tillknytning
2012 (engelsk)Inngår i: Journal of nanoparticle research, ISSN 1388-0764, E-ISSN 1572-896X, Vol. 14, nr 8, artikkel-id 1006Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Chelated gadolinium ions, e.g., Gd-DTPA, are today used clinically as contrast agents for magnetic resonance imaging (MRI). An attractive alternative contrast agent is composed of gadolinium oxide nanoparticles as they have shown to provide enhanced contrast and, in principle, more straightforward molecular capping possibilities. In this study, we report a new, simple, and polyol-free way of synthesizing 4-5-nm-sized Gd 2O 3 nanoparticles at room temperature, with high stability and water solubility. The nanoparticles induce high-proton relaxivity compared to Gd-DTPA showing r 1 and r 2 values almost as high as those for free Gd 3+ ions in water. The Gd 2O 3 nanoparticles are capped with acetate and carbonate groups, as shown with infrared spectroscopy, near-edge X-ray absorption spectroscopy, X-ray photoelectron spectroscopy and combined thermogravimetric and mass spectroscopy analysis. Interpretation of infrared spectroscopy data is corroborated by extensive quantum chemical calculations. This nanomaterial is easily prepared and has promising properties to function as a core in a future contrast agent for MRI. 

sted, utgiver, år, opplag, sider
Springer, 2012. Vol. 14, nr 8, artikkel-id 1006
Emneord [en]
Gadolinium oxide, IR, Relaxivity, Synthesis, Toxicity, XPS, Carbonate group, Contrast agent, Enhanced contrast, Gadolinium ions, Gd-DTPA, High stability, Mass spectroscopy, Nanomaterial, Near-edge x-ray absorption, Quantum chemical calculations, Room temperature, Synthesis route, Theoretical study, Thermogravimetric, Water solubilities, X-ray photoelectrons, Alcohols, Infrared spectroscopy, Iridium, Magnetic resonance imaging, Mass spectrometry, Nanoparticles, Photoelectrons, Quantum chemistry, Synthesis (chemical), Thermogravimetric analysis, X ray absorption spectroscopy, X ray photoelectron spectroscopy, Gadolinium, gadolinium chloride, gadolinium oxide nanoparticle, gadolinium pentetate, nanoparticle, nuclear magnetic resonance imaging agent, polyol, unclassified drug, article, chemical composition, drug synthesis, light scattering, molecular stability, nuclear magnetic resonance imaging, particle size, priority journal, thermogravimetry, transmission electron microscopy, X ray diffraction
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Identifikatorer
URN: urn:nbn:se:kth:diva-198742DOI: 10.1007/s11051-012-1006-2ISI: 000307273400028Scopus ID: 2-s2.0-84863468049OAI: oai:DiVA.org:kth-198742DiVA, id: diva2:1059076
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QC 20240112

Tilgjengelig fra: 2016-12-22 Laget: 2016-12-21 Sist oppdatert: 2024-03-15bibliografisk kontrollert

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Norman, Patrick
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