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A Biopsychosocial Approach to Risk and Resilience on Behavior in Children Followed from Birth to Age 12
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Neuroscience, Neuro-psycho-pharmacology.
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2017 (English)In: Child Psychiatry and Human Development, ISSN 0009-398X, E-ISSN 1573-3327, Vol. 48, no 4, p. 584-596Article in journal (Refereed) Published
Abstract [en]

An increasing prevalence of mental health problems calls for more knowledge into factors associated with resilience. The present study used multiple statistical methodologies to examine a biopsychosocial model of risk and resilience on preadolescence behavior. Data from 889 children and mothers from a birth cohort were used. An adversity score was created by combining maternal symptoms of depression, psychosocial risk and children's experiences of life events. The proposed resilience factors investigated were candidate genetic polymorphisms, child temperament, social functioning, and maternal sense of coherence. The l/l genotype of the serotonin transporter linked polymorphic region was associated with lower internalizing scores, but not mainly related to the level of adversity. An easy temperament was associated with resilience for children exposed to high adversity. Social functioning was found to be promotive independent of the risk level. The results support a multiple-level model of resilience indicating effects, though small, of both biological and psychosocial factors.

Place, publisher, year, edition, pages
2017. Vol. 48, no 4, p. 584-596
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:uu:diva-309062DOI: 10.1007/s10578-016-0684-xISI: 000410242400007PubMedID: 27628896OAI: oai:DiVA.org:uu-309062DiVA, id: diva2:1051514
Funder
Forte, Swedish Research Council for Health, Working Life and WelfareSwedish Research CouncilAvailable from: 2016-12-02 Created: 2016-12-02 Last updated: 2017-12-11Bibliographically approved

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