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Reduced serotonin synthesis and regional cerebral blood flow after anxiolytic treatment of social anxiety disorder
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi.ORCID-id: 0000-0003-2516-9075
Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Samhällsvetenskapliga fakulteten, Institutionen för psykologi. Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
Vise andre og tillknytning
2016 (engelsk)Inngår i: European Neuropsychopharmacology, ISSN 0924-977X, E-ISSN 1873-7862, Vol. 26, nr 11, s. 1775-1783Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Abstract Social anxiety disorder (SAD) is associated with increased fear-related neural activity in the amygdala and we recently found enhanced serotonin synthesis rate in the same region. Anxiolytic agents like selective serotonin re-uptake inhibitors (SSRIs) and neurokinin-1 receptor (NK1R) antagonists reduce amygdala activity and may attenuate serotonin formation according to animal studies. Here, we examined the effects of SSRI pharmacotherapy, NK1R antagonism, and placebo on serotonin synthesis rate in relation to neural activity, measured as regional cerebral blood flow (rCBF), and symptom improvement in SAD. Eighteen SAD patients were randomized to receive daily double-blind treatment for six weeks either with the SSRI citalopram (n=6; 40 mg), the NK1R antagonist GR205171 (n=6; 5 mg; 4 weeks following 2 weeks of placebo), or placebo (n=6). Serotonin synthesis rate at rest and rCBF during stressful public speaking were assessed, before and after treatment, using positron emission tomography with the tracers [11C]5-hydroxytryptophan and [15O]water respectively. The Liebowitz Social Anxiety Scale (LSAS-SR) indexed symptom severity. All groups exhibited attenuated amygdala serotonin synthesis rate after treatment, which was associated with reduced amygdala rCBF during public speaking and accompanied by symptom improvement. These results are consistent with the notion that serotonin in the amygdala exerts an anxiogenic influence and, conversely, that anxiolysis is achieved through decreased serotonin formation in the amygdala.

sted, utgiver, år, opplag, sider
2016. Vol. 26, nr 11, s. 1775-1783
Emneord [en]
Social phobia, 5-HT, NK1, Positron emission tomography, SSRI
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-306707DOI: 10.1016/j.euroneuro.2016.09.004ISI: 000387523600006PubMedID: 27642077OAI: oai:DiVA.org:uu-306707DiVA, id: diva2:1044203
Forskningsfinansiär
Swedish Research CouncilThe Swedish Brain FoundationForte, Swedish Research Council for Health, Working Life and WelfareGlaxoSmithKline (GSK)Tilgjengelig fra: 2016-11-02 Laget: 2016-11-02 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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Frick, AndreasÅhs, FredrikAppel, LieuweJonasson, MyLångström, BengtLubberink, MarkFredriksson, MatsFurmark, Tomas
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