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Associations between EBV and CMV Seropositivity, Early Exposures, and Gut Microbiota in a Prospective Birth Cohort: A 10-Year Follow-up
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Stockholms universitet, Naturvetenskapliga fakulteten, Institutionen för molekylär biovetenskap, Wenner-Grens institut.
Stockholms universitet, Naturvetenskapliga fakulteten, Matematiska institutionen.
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Antal upphovsmän: 82016 (Engelska)Ingår i: Frontiers in Pediatrics, ISSN 2296-2360, Vol. 4, artikel-id 93Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Early-life infections with persistent Epstein-Barr virus (EBV) and cytomegalovirus (CMV) are delayed in affluent countries, probably due to alterations in early environmental exposures, such as maternal age, siblings, and day-care attendance. We have previously reported that the timing of EBV and CMV contraction is related both to allergic sensitization and changes in functional competence of immune cells, while the presence/absence of lactobacilli [Lactobacillus (L.) casei, L. paracasei, and L. rhamnosus] or Staphylococcus (S.) aureus in feces is related to the risk for allergy. Here, we used the same prospective longitudinal birth cohort of children to investigate early-life environmental exposures and their influence on EBV and CMV contraction over time. Since gut microbes also belong to this category of early exposures, we investigated their association with herpesvirus contraction. Our results show that these two viruses are acquired with different kinetics and that EBV and CMV seroprevalence at 10 years of age was 47 and 57%, respectively. We also observed that a delayed EBV or CMV infection was associated with older maternal age [time ratio (TR) 1.14, 95% confidence interval (CI) 1.07-1.21, P-adj < 0.001 and TR 1.09, CI 1.03-1.16, P-adj = 0.008, respectively]. Further, we present the novel finding that S. aureus colonization reduced the time to CMV acquisition (TR 0.21, CI 0.06-0.78, = 0.02). Together, these findings suggest that there is a relationship between timing of herpesvirus acquisition and early-life immune modulating exposures, which interestingly also includes the early infant gut microbiota.

Ort, förlag, år, upplaga, sidor
2016. Vol. 4, artikel-id 93
Nyckelord [en]
healthy children, EBV, CMV, seroprevalence, risk factors, gut microbiota, S. aureus, Lactobacillus
Nationell ämneskategori
Biologiska vetenskaper Pediatrik
Identifikatorer
URN: urn:nbn:se:su:diva-134409DOI: 10.3389/fped.2016.00093ISI: 000382294800001PubMedID: 27630978OAI: oai:DiVA.org:su-134409DiVA, id: diva2:1039566
Tillgänglig från: 2016-10-24 Skapad: 2016-10-06 Senast uppdaterad: 2016-10-24Bibliografiskt granskad

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Av författaren/redaktören
Johansson, Maria A.Persson, Jan-OlovSverremark-Ekström, Eva
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Institutionen för molekylär biovetenskap, Wenner-Grens institutMatematiska institutionen
Biologiska vetenskaperPediatrik

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