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Aspirin and risk for gastric cancer: a population-based case-control study in Sweden
Department of Medical Epidemiology, Karolinska Institutet, Stockholm.ORCID-id: 0000-0002-3649-2639
Department of Medical Epidemiology, Karolinska Institutet, Stockholm.
2International Epidemiology Institute, Rockville, USA.
Mora Hospital, Mora.
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2001 (Engelska)Ingår i: British Journal of Cancer, ISSN 0007-0920, E-ISSN 1532-1827, Vol. 84, nr 7, s. 965-8Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

While aspirin and other non-steroid anti-inflammatory drugs (NSAIDs) are associated with gastric mucosal damage, they might reduce the risk for gastric cancer. In a population-based case-control study in 5 Swedish counties, we interviewed 567 incident cases of gastric cancer and 1165 controls about their use of pain relievers. The cases were uniformly classified to subsite (cardia/non-cardia) and histological type and information collected on other known risk factors for gastric cancer. Helicobacter pylori serology was tested in a subset of 542 individuals. Users of aspirin had a moderately reduced risk of gastric cancer compared to never users; odds ratio (OR) adjusted for age, gender and socioeconomic status was 0.7 (95% CI = 0.6-1.0). Gastric cancer risk fell with increasing frequency of aspirin use (P for trend = 0.02). The risk reduction was apparent for both cardia and non-cardia tumours but was uncertain for the diffuse histologic type. No clear association was observed between gastric cancer risk and non-aspirin NSAIDs or other studied pain relievers. Our finding lends support to the hypothesis that use of aspirin reduces the risk for gastric cancer.

Ort, förlag, år, upplaga, sidor
Edinburgh, United Kingdom: Churchill Livingstone , 2001. Vol. 84, nr 7, s. 965-8
Nyckelord [en]
Gastric cancer, aspirin, NSAIDs, elicobacter pylori
Nationell ämneskategori
Medicin och hälsovetenskap Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:oru:diva-44593DOI: 10.1054/bjoc.2001.1702ISI: 000168198300016PubMedID: 11286478Scopus ID: 2-s2.0-0035815222OAI: oai:DiVA.org:oru-44593DiVA, id: diva2:811685
Tillgänglig från: 2015-05-12 Skapad: 2015-05-11 Senast uppdaterad: 2017-12-04Bibliografiskt granskad

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