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Global emergence of Alphaviruses that cause arthritis in humans
Umeå universitet, Medicinska fakulteten, Institutionen för klinisk mikrobiologi, Virologi.
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2015 (Engelska)Ingår i: Infection Ecology & Epidemiology, ISSN 2000-8686, E-ISSN 2000-8686, Vol. 5, artikel-id 29853Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Arthropod-borne viruses (arboviruses) may cause severe emerging and re-emerging infectious diseases, which pose a significant threat to human and animal health in the world today. These infectious diseases range from mild febrile illnesses, arthritis, and encephalitis to haemorrhagic fevers. It is postulated that certain environmental factors, vector competence, and host susceptibility have a major impact on the ecology of arboviral diseases. Presently, there is a great interest in the emergence of Alphaviruses because these viruses, including Chikungunya virus, O'nyong'nyong virus, Sindbis virus, Ross River virus, and Mayaro virus, have caused outbreaks in Africa, Asia, Australia, Europe, and America. Some of these viruses are more common in the tropics, whereas others are also found in temperate regions, but the actual factors driving Alphavirus emergence and re-emergence remain unresolved. Furthermore, little is known about the transmission dynamics, pathophysiology, genetic diversity, and evolution of circulating viral strains. In addition, the clinical presentation of Alphaviruses may be similar to other diseases such as dengue, malaria, and typhoid, hence leading to misdiagnosis. However, the typical presence of arthritis may distinguish between Alphaviruses and other differential diagnoses. The absence of validated diagnostic kits for Alphaviruses makes even routine surveillance less feasible. For that purpose, this review describes the occurrence, genetic diversity, clinical characteristics, and the mechanisms involving Alphaviruses causing arthritis in humans. This information may serve as a basis for better awareness and detection of Alphavirus-caused diseases during outbreaks and in establishing appropriate prevention and control measures.

Ort, förlag, år, upplaga, sidor
2015. Vol. 5, artikel-id 29853
Nyckelord [en]
arthritis, chikungunya, O’nyong’nyong, Sindbis, Ross River, Mayaro
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Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:umu:diva-121283DOI: 10.3402/iee.v5.29853PubMedID: 26689654OAI: oai:DiVA.org:umu-121283DiVA, id: diva2:931855
Tillgänglig från: 2016-05-30 Skapad: 2016-05-30 Senast uppdaterad: 2018-06-07Bibliografiskt granskad

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