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The HemoScreen, a novel haematology analyser for the point of care
PixCell Med Technol Ltd, Yokneam Ilit, Israel.
PixCell Med Technol Ltd, Yokneam Ilit, Israel.
PixCell Med Technol Ltd, Yokneam Ilit, Israel.
Univ Westminster, Fac Sci & Technol, Biomed Sci, London, England.
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2016 (Engelska)Ingår i: Journal of Clinical Pathology, ISSN 0021-9746, E-ISSN 1472-4146, Vol. 69, nr 8, s. 720-725Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND AND AIMS: A haematology analyser, based on a new technology, is presented herein. The analyser that provides a complete blood count (CBC) and five-part differential accepts disposable cartridges containing all required reagents, making it maintenance-free and ideal for point-of-care (POC) settings. The test reproducibility and imperviousness to analytical errors are attributed to the imaging-based analysis employed. Imaging enables cell-morphology-based differentiation, which is analogous to the gold standard microscopic analysis. This article presents the HemoScreen new technology and evaluates its performance through a small-scale study conducted in its designated clinical settings.

METHODS: Thirty anticoagulated whole blood samples were analysed on the HemoScreen and Sysmex XE-2100. Linear regression was performed for the methods comparison. Two samples with 15 replicates were processed for imprecision. Ease of use of the device was also considered.

RESULTS: The HemoScreen demonstrated acceptable imprecision and good agreement with the Sysmex XE-2100. The white blood cells (WBCs), red blood cells (RBCs), haemoglobin (HGB), haematocrit (HCT), platelets (PLT), neutrophils, lymphocytes and eosinophils have coefficients of correlation (r) >0.97. For mean cell volume (MCV), mean cell HGB (MCH) and RBC distribution width (RDW), r values ranged from 0.92 to 0.96. For mean cell HGB concentration (MCHC) and monocytes r=0.82 was demonstrated. User-friendliness and suitability of the device for operation in the designated POC settings was also confirmed.

CONCLUSIONS: The HemoScreen employs innovative technologies of viscoelastic focusing and microfluidics within a disposable cartridge for an image-based blood cell analysis. By providing accurate and repeatable CBC and five-part differential results within minutes and maintaining the simplicity of operation, the HemoScreen could have far-reaching implications for use at POC. Further extended evaluation is in progress.

Ort, förlag, år, upplaga, sidor
2016. Vol. 69, nr 8, s. 720-725
Nationell ämneskategori
Hematologi
Identifikatorer
URN: urn:nbn:se:uu:diva-274581DOI: 10.1136/jclinpath-2015-203484ISI: 000380803000009PubMedID: 26786235OAI: oai:DiVA.org:uu-274581DiVA, id: diva2:896991
Tillgänglig från: 2016-01-23 Skapad: 2016-01-23 Senast uppdaterad: 2017-11-30Bibliografiskt granskad

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