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A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27(-)IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
Stockholms universitet, Naturvetenskapliga fakulteten, Wenner-Grens institut, Avdelningen för immunologi.
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2013 (Engelska)Ingår i: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 149, nr 3, s. 421-431Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27(+) B cells formed after transplantation with the number of CD27(+)IgM(high) cells more affected than class-switched ones. A previously unacknowledged population of CD27(-)IgM(high) cells made up the majority of B cells and this population was also enlarged in healthy children compared to adults. Only a minority of these CD27(-)IgM(high) B cells expressed markers typical for transitional B cells, and the non-transitional CD27(-)IgM(high) cells could be further divided into subpopulations based on their ability to extrude the dye Rhodamine 123 and their expression of CD45RB(MEM55), a glycosylation-dependent epitope. Thus, we define several novel human CD27(-)IgM(high) B cell subpopulations in blood, all of which are present in higher frequencies and numbers in young children and after HSCT than in adults.

Ort, förlag, år, upplaga, sidor
2013. Vol. 149, nr 3, s. 421-431
Nyckelord [en]
Hematopoietic stem cell transplantation, B cell, Lymphocyte development, Immunological ontogeny
Nationell ämneskategori
Immunologi
Identifikatorer
URN: urn:nbn:se:su:diva-100114DOI: 10.1016/j.clim.2013.08.011ISI: 000328874800007OAI: oai:DiVA.org:su-100114DiVA, id: diva2:691563
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AuthorCount:9;

Tillgänglig från: 2014-01-28 Skapad: 2014-01-27 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

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Sverremark-Ekström, Eva
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Clinical Immunology
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