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Five-Year Follow-Up After Transcatheter Aortic Valve Implantation in Patients with Severe Aortic Stenosis and Concomitant Coronary Artery Disease: A Single-Center Experience
Department of Radiology, Örebro University Hospital, Örebro, Sweden.
Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro universitet, Institutionen för medicinska vetenskaper. Department of Cardiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID-id: 0000-0002-5846-345X
Region Örebro län. Örebro universitet, Institutionen för medicinska vetenskaper. University Health Care Research Centre.ORCID-id: 0000-0003-4249-8401
2023 (Engelska)Ingår i: Brazilian Journal of Cardiovascular Surgery, ISSN 0102-7638, E-ISSN 1678-9741, Vol. 39, nr 1, artikel-id e20220461Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

INTRODUCTION: There is no consensus on the impact of coronary artery disease in patients undergoing transcatheter aortic valve implantation. Therefore, the objective of this study was, in a single-center setting, to evaluate the five-year outcome of transcatheter aortic valve implantation patients with or without coronary artery disease.

METHODS: All transcatheter aortic valve implantation patients between 2009 and 2019 were included and grouped according to the presence or absence of coronary artery disease. The primary endpoint, five-year all-cause mortality, was evaluated using Cox regression adjusted for age, sex, procedure years, and comorbidities. Comorbidities interacting with coronary artery disease were evaluated with interaction tests. In-hospital complications was the secondary endpoint.

RESULTS: In total, 176 patients had aortic stenosis and concomitant coronary artery disease, while 170 patients had aortic stenosis only. Mean follow-up was 2.2±1.6 years. There was no difference in the adjusted five-year all-cause mortality between transcatheter aortic valve implantation patients with and without coronary artery disease (hazard ratio 1.00, 95% confidence interval 0.59-1.70, P=0.99). In coronary artery disease patients, impaired renal function, peripheral arterial disease, or ejection fraction < 50% showed a significant interaction effect with higher five-year all-cause mortality. No significant differences in complications between the groups were found.

CONCLUSION: Five-year mortality did not differ between transcatheter aortic valve implantation patients with or without coronary artery disease. However, in patients with coronary artery disease and impaired renal function, peripheral arterial disease, or ejection fraction < 50%, we found significantly higher five-year all-cause mortality.

Ort, förlag, år, upplaga, sidor
Sociedade Brasileira de Cirurgia Cardiovascular , 2023. Vol. 39, nr 1, artikel-id e20220461
Nyckelord [en]
Aortic Stenosis, Coronary Artery Bypass Grafting, Coronary Artery Disease, Percutaneous Coronary Intervention, Transcatheter Aortic Valve Implantation
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:oru:diva-109504DOI: 10.21470/1678-9741-2022-0461ISI: 001094178200003PubMedID: 37889212Scopus ID: 2-s2.0-85175194857OAI: oai:DiVA.org:oru-109504DiVA, id: diva2:1808744
Tillgänglig från: 2023-11-01 Skapad: 2023-11-01 Senast uppdaterad: 2024-03-06Bibliografiskt granskad

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Fröbert, OleSamano, Ninos
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Institutionen för medicinska vetenskaperRegion Örebro län
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