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NiOX Template-Grown Ni-MOF-Coated Carbon Paper Electrode Embedded Extended Gate Field Effect Transistor for Glucose Detection in Saliva: En Route toward the Noninvasive Diagnosis of Diabetes Mellitus
SRM Institute of Science and Technology, India.
SRM Institute of Science and Technology, India.
SRM Institute of Science and Technology, India.
RISE Research Institutes of Sweden, Digitala system, Smart hårdvara.ORCID-id: 0000-0002-1949-6144
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2023 (Engelska)Ingår i: ACS Applied Electronic Materials, ISSN 2637-6113, Vol. 5, nr 6, s. 3268-Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Our present work focuses on the development of nickel oxalate (NiOX) template-assisted growth of a nickel-metal organic framework (Ni-MOF) with sheetlike morphology on carbon paper (CP) electrode for the noninvasive detection of glucose. We have utilized an extended gate field effect transistor (EGFET) where the Ni-MOF/CP electrode serves as the extended gate of a commercial n-type metal oxide semiconductor FET for sensing glucose. The electrode detects glucose concentrations ranging from 20 μM to 1.47 mM. The sensor operates at a voltage of 0.7 V in the physiologically relevant electrolyte of phosphate-buffered saline (PBS) with a response time of less than 5 s. The sensitivity is calculated as 86 μA mM-1 cm-2 from the linear region of the sensor response to the glucose concentration (20 μM to 0.27 mM). Also, Ni-MOF/CP has shown a good selective response toward glucose against uric acid, sucrose, fructose, and ascorbic acid. Additionally, the glucose sensing mechanism is investigated through work function changes of the sensing electrode using a scanning Kelvin probe. Real-time sample testing has revealed that the sensor preserves the sensitivity in human saliva too. In summary, we conclude that the Ni-MOF/CP extended gate electrode EGFET is an alternative device for salivary glucose detection toward the noninvasive diagnosis of diabetes mellitus that can identify hyperglycemic, normal, and hypoglycemic conditions. 

Ort, förlag, år, upplaga, sidor
American Chemical Society , 2023. Vol. 5, nr 6, s. 3268-
Nyckelord [en]
diabetes mellitus, EGFET, nickel MOF on carbon paper, noninvasive glucose detection, saliva, scanning Kelvin probe, Carbon, Electrolytes, Field effect transistors, Glucose, Glucose sensors, MOS devices, Nickel compounds, Organometallics, Oxide semiconductors, Paper, Physiological models, Probes, Refractory metal compounds, Carbon paper, Extended-gate field-effect transistors, Glucose detection, Metalorganic frameworks (MOFs), Non-invasive diagnosis, Scanning Kelvin probes, Electrodes
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URN: urn:nbn:se:ri:diva-65538DOI: 10.1021/acsaelm.3c00339Scopus ID: 2-s2.0-85161068577OAI: oai:DiVA.org:ri-65538DiVA, id: diva2:1776533
Anmärkning

This work is supported by the Science and Engineering Research Board (SERB), Department of Science and Technology (DST), Government of India, under ECRA (file no. ECR/2017/001218) and CRG (file no. CRG/2021/006647).

Tillgänglig från: 2023-06-28 Skapad: 2023-06-28 Senast uppdaterad: 2024-06-07Bibliografiskt granskad

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