Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
A study of neural activity and functional connectivity within the olfactory brain network in Parkinson's disease
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.ORCID-id: 0000-0001-7433-0203
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: NeuroImage: Clinical, ISSN 0353-8842, E-ISSN 2213-1582, Vol. 23, artikel-id 101946Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Olfactory dysfunction is an early manifestation of Parkinson's disease (PD). The present study aimed to illustrate potential differences between PD patients and healthy controls in terms of neural activity and functional connectivity within the olfactory brain network. Twenty PD patients and twenty healthy controls were examined with olfactory fMRI and resting-state fMRI. Data analysis of olfactory fMRI included data-driven tensorial independent component (ICA) and task-driven general linear model (GLM) analyses. Data analysis of resting-state fMRI included probabilistic ICA based on temporal concatenation and functional connectivity analysis within the olfactory network. ICA of olfactory fMRI identified an olfactory network consisting of the posterior piriform cortex, insula, right orbitofrontal cortex and thalamus. Recruitment of this network was less significant for PD patients. GLM analysis revealed significantly lower activity in the insula bilaterally and the right orbitofrontal cortex in PD compared to healthy controls but no significant differences in the olfactory cortex itself. Analysis of resting-state fMRI did not reveal any differences in the functional connectivity within the olfactory, default mode, salience or central executive networks between the two groups. In conclusion, olfactory dysfunction in PD is associated with less significant recruitment of the olfactory brain network. ICA could demonstrate differences in both the olfactory cortex and its main projections, compared to GLM that revealed differences only on the latter. Resting-state fMRI did not reveal any significant differences in functional connectivity within the olfactory, default mode, salience and central executive networks in this cohort.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 23, artikel-id 101946
Nyckelord [en]
Functional connectivity, Olfaction, Parkinson, fMRI
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:uu:diva-392823DOI: 10.1016/j.nicl.2019.101946ISI: 000485804400125PubMedID: 31491835OAI: oai:DiVA.org:uu-392823DiVA, id: diva2:1349949
Tillgänglig från: 2019-09-10 Skapad: 2019-09-10 Senast uppdaterad: 2019-10-25Bibliografiskt granskad

Open Access i DiVA

fulltext(1421 kB)16 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 1421 kBChecksumma SHA-512
49fcb22ead3210e160025d32b69e32554d417357ba2ed78c5a40910127b469779e157c466b97b5ca2370d6d3e137ce44b89c30961a811bb05e87771016a78262
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Haller, SvenLarsson, Elna-Marie
Av organisationen
Radiologi
I samma tidskrift
NeuroImage: Clinical
Neurovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 16 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 21 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf