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Prostate cancer induces C/EBP expression in surrounding epithelial cells which relates to tumor aggressiveness and patient outcome
Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden.
Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden.
Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden.
Umea Univ, Dept Med Biosci, Pathol, 6M, Umea, Sweden.
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2019 (Engelska)Ingår i: The Prostate, ISSN 0270-4137, E-ISSN 1097-0045, Vol. 79, nr 5, s. 435-445Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Implantation of rat prostate cancer cells into the normal rat prostate results in tumor-stimulating adaptations in the tumor-bearing organ. Similar changes are seen in prostate cancer patients and they are related to outcome. One gene previously found to be upregulated in the non-malignant part of tumor-bearing prostate lobe in rats was the transcription factor CCAAT/enhancer-binding protein- (C/EBP).

Methods: To explore this further, we examined C/EBP expression by quantitative RT-PCR, immunohistochemistry, and Western blot in normal rat prostate tissue surrounding slow-growing non-metastatic Dunning G, rapidly growing poorly metastatic (AT-1), and rapidly growing highly metastatic (MatLyLu) rat prostate tumors?and also by immunohistochemistry in a tissue microarray (TMA) from prostate cancer patients managed by watchful waiting.

Results: In rats, C/EBP mRNA expression was upregulated in the surrounding tumor-bearing prostate lobe. In tumors and in the surrounding non-malignant prostate tissue, C/EBP was detected by immunohistochemistry in some epithelial cells and in infiltrating macrophages. The magnitude of glandular epithelial C/EBP expression in the tumor-bearing prostates was associated with tumor size, distance to the tumor, and metastatic capacity. In prostate cancer patients, high expression of C/EBP in glandular epithelial cells in the surrounding tumor-bearing tissue was associated with accumulation of M1 macrophages (iNOS+) and favorable outcome. High expression of C/EBP in tumor epithelial cells was associated with high Gleason score, high tumor cell proliferation, metastases, and poor outcome.

Conclusions: This study suggest that the expression of C/EBP-beta, a transcription factor mediating multiple biological effects, is differentially expressed both in the benign parts of the tumor-bearing prostate and in prostate tumors, and that alterations in this may be related to patient outcome.

Ort, förlag, år, upplaga, sidor
WILEY , 2019. Vol. 79, nr 5, s. 435-445
Nyckelord [en]
biomarkers, C, EBP, prostate cancer, tumors instruct adjacent tissues
Nationell ämneskategori
Cancer och onkologi Urologi och njurmedicin
Identifikatorer
URN: urn:nbn:se:uu:diva-381118DOI: 10.1002/pros.23749ISI: 000461573200001PubMedID: 30536410OAI: oai:DiVA.org:uu-381118DiVA, id: diva2:1302550
Forskningsfinansiär
Vetenskapsrådet, Co257301Cancerfonden, 130293Tillgänglig från: 2019-04-05 Skapad: 2019-04-05 Senast uppdaterad: 2019-04-05Bibliografiskt granskad

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