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Associations Between the Prevalence of Metabolic Syndrome and Sleep Parameters Vary by Age
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Funktionell farmakologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Lung- allergi- och sömnforskning.
Lund Univ, CRC, Dept Hlth Sci, Div Geriatr Med,Skane Univ Hosp, Malmo, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiovaskulär epidemiologi.ORCID-id: 0000-0003-2335-8542
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: Frontiers in Endocrinology, ISSN 1664-2392, E-ISSN 1664-2392, Vol. 9, artikel-id 234Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To examine whether the relationship between the metabolic syndrome (MetS) and various sleep parameters [sleep duration, symptoms of sleep-disordered breathing (SDB), and sleep disturbances] varies by age. Methods: Waist circumference, blood pressure, triglycerides, high-density lipoprotein cholesterol, and fasting glucose were used to determine MetS status in a cohort (N = 19,691) of middle-aged (aged 45-64 years) and older (aged >= 65 years) subjects. Habitual sleep duration (short, <= 6 h/day; normal, 7-8 h/day; and long >= 9 h/day), sleep disturbances (such as problems with falling and staying asleep), and symptoms of sleep-disordered breathing (SDB, such as snoring and sleep apneas) were measured by questionnaires. Results: Among the participants, 4,941 subjects (25.1%) fulfilled the criteria for MetS. In the entire sample, both short and long sleep durations were associated with higher prevalence of MetS as compared to normal sleep duration. When stratified by age, a similar pattern was observed for middle-aged subjects (<65 years old; prevalence ratio (PR) [95% CI], 1.13 [1.06-1.22] for short sleep and 1.26 [1.06-1.50] for long sleep duration). In contrast, in older individuals (>= 65 years old), only long sleep duration was linked to a higher prevalence of MetS (1.26 [1.12-1.42]; P < 0.01 for sleep duration x age). In the entire cohort, having at least one SDB symptom >= 4 times per week was linked to an increased prevalence of MetS; however, the PR was higher in middle-aged subjects compared with older subjects (1.50 [1.38-1.63] vs. 1.36 [1.26-1.47], respectively; P < 0.001 for SDB x age). Finally, independent of subjects' age, reports of sleep disturbances (i.e., at least one symptom >= 4 times per week) were associated with a higher likelihood of having MetS (1.12 [1.06-1.18]; P > 0.05 for sleep disturbance x age). Conclusion: Our results suggest that age may modify the associations between some sleep parameters and the prevalence of MetS.

Ort, förlag, år, upplaga, sidor
2018. Vol. 9, artikel-id 234
Nyckelord [en]
sleep duration, sleep disturbance, sleep-disordered breathing, metabolic syndrome, age
Nationell ämneskategori
Lungmedicin och allergi
Identifikatorer
URN: urn:nbn:se:uu:diva-356873DOI: 10.3389/fendo.2018.00234ISI: 000431867800001PubMedID: 29867766OAI: oai:DiVA.org:uu-356873DiVA, id: diva2:1237638
Forskningsfinansiär
Vetenskapsrådet, 2015-03100HjärnfondenNovo Nordisk, NNF14OC0009349Tillgänglig från: 2018-08-09 Skapad: 2018-08-09 Senast uppdaterad: 2019-03-15Bibliografiskt granskad
Ingår i avhandling
1. Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
Öppna denna publikation i ny flik eller fönster >>Metabolic Health and Cognitive Function: The Roles of Lifestyle and Shift Work
2019 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

The risk of cognitive impairment and metabolic disturbances increases during aging. Healthy lifestyle habits, such as a regular intake of fatty fish and adherence to the Mediterranean diet (MeDi), have been shown to slow age-related cognitive decline and decrease the risk of metabolic disturbances. Conversely, poor lifestyle habits including habitual short sleep duration as well as irregular work schedules (e.g. night shift work) have been correlated with lower cognitive performance and increased risk of having metabolic syndrome (MetS). However evidence is not conclusive regarding the above mentioned associations. The aim of this thesis was to investigate associations of diet, sleep, and shift work with metabolic health or cognitive performance in two Swedish cohorts.

In Paper I and II we examined whether the dietary intake of omega-3 fatty acids and adherence to MeDi were related to measures of brain health in elderly subjects. To this aim, we used scores from the 7-minute cognitive screening test (7MS) and brain volume determined by magnetic resonance imaging. In Paper I, self-reported dietary intake of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) at age 70 was positively associated with cognitive performance and global gray matter volume at age 75. In Paper II, the fully-adjusted main analysis revealed that the MeDi score was not linked to measures of brain health. However, low intake of the MeDi component meat and meat products was associated with better performance on the 7MS and larger total brain volume.

Paper III and IV included subjects aged 45-75 years. In Paper III we demonstrated that current and recent former shift workers (including shifts outside traditional working hours during the past 5 years at the time of the survey) performed worse on the trail making test (TMT) than non-shift workers. The TMT is a test evaluating executive cognitive function, and the performance on this test decreases with age. In Paper IV, sleep duration, sleep disturbances, and sleep-disordered breathing were all linked to an increased prevalence of MetS. Some of the observed associations were age-specific. For example, whereas both short and long sleep durations were linked to a higher prevalence of MetS in younger individuals (<65 years), only long sleep duration did so in the older participants. Collectively, the findings of this thesis suggest that maintaining healthy dietary habits, having high-quality sleep, and following a regular work schedule may be recommended strategies to mitigate age-related morbidities.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 58
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1532
Nyckelord
cognitive function, Mediterranean diet, omega-3 fatty acids, MRI, shift work history, sleep, metabolic syndrome
Nationell ämneskategori
Medicin och hälsovetenskap
Forskningsämne
Epidemiologi; Medicinsk vetenskap
Identifikatorer
urn:nbn:se:uu:diva-368737 (URN)978-91-513-0557-8 (ISBN)
Disputation
2019-03-07, A1:107a, BMC, Husargatan 3, Uppsala, 10:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2019-02-14 Skapad: 2019-01-17 Senast uppdaterad: 2019-02-18

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