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The inherited risk of retained placenta: a population based cohort study.
Karolinska Inst, Dept Clin Sci & Educ, Södersjukhuset, Stockholm, Sweden.
Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Klinisk obstetrik. Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.ORCID-id: 0000-0002-6311-9506
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Klinisk obstetrik. Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden.
2018 (Engelska)Ingår i: British Journal of Obstetrics and Gynecology, ISSN 1470-0328, E-ISSN 1471-0528, Vol. 125, nr 6, s. 737-744Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Objective: To investigate whether retained placenta in the first generation is associated with an increased risk of retained placenta in the second generation.

Design: Population‐based cohort study.

Setting: Sweden.

Population: Using linked generational data from the Swedish Medical Birth Register 1973–2012, we identified 494 000 second‐generation births with information on the birth of the mother (first‐generation index birth). For 292 897 of these births there was information also on the birth of the father.

Methods: Risk of retained placenta in the second generation was calculated as adjusted odds ratios (aOR) by unconditional logistic regression with 95% confidence intervals (95% CI) according to whether retained placenta occurred in a first generation birth or not.

Main outcome: Retained placenta in the second generation.

Results: The risk of retained placenta in a second‐generation birth was increased if retained placenta had occurred at the mother's own birth (aOR 1.66, 95% CI 1.52–1.82), at the birth of one of her siblings (aOR 1.58, 95% CI 1.43–1.76) or both (aOR 2.75, 95% CI 2.18–3.46). The risk was slightly increased if retained placenta had occurred at the birth of the father (aOR 1.23, 95% CI 1.07–1.41). For preterm births in both generations, the risk of retained placenta in the second generation was increased six‐fold if retained placenta had occurred at the mother's birth (OR 6.55, 95% CI 2.68–16.02).

Conclusion: There is an intergenerational recurrence of retained placenta on the maternal and most likely also on the paternal side. The recurrence risk seems strongest in preterm pregnancies.

Tweetable abstract: A population‐based cohort study suggests that there is an intergenerational recurrence of retained placenta.

Ort, förlag, år, upplaga, sidor
2018. Vol. 125, nr 6, s. 737-744
Nyckelord [en]
inherited risk, retained placenta
Nationell ämneskategori
Reproduktionsmedicin och gynekologi
Forskningsämne
Obstetrik och gynekologi
Identifikatorer
URN: urn:nbn:se:uu:diva-336792DOI: 10.1111/1471-0528.14828ISI: 000431000400022PubMedID: 28731581OAI: oai:DiVA.org:uu-336792DiVA, id: diva2:1167053
Forskningsfinansiär
Vetenskapsrådet, 2014-3561Tillgänglig från: 2017-12-17 Skapad: 2017-12-17 Senast uppdaterad: 2018-08-10Bibliografiskt granskad

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Granfors, MichaelaWikström, Anna-Karin
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Klinisk obstetrik
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Reproduktionsmedicin och gynekologi

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