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Stimuli-Responsive, Multivalent Glycodendrimer/Metalloglycodendrimer Assemblies for Targeted Delivery
KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.ORCID-id: 0000-0003-2865-2513
KTH, Skolan för kemivetenskap (CHE), Kemi, Organisk kemi.
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
Emneord [en]
Glycodendrimers, metalloglycodendrimers, self-assembly, stimuli-responsive, drug delivery
HSV kategori
Forskningsprogram
Kemi
Identifikatorer
URN: urn:nbn:se:kth:diva-177277OAI: oai:DiVA.org:kth-177277DiVA, id: diva2:872075
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, KDHH B61632
Merknad

QS 201511

Tilgjengelig fra: 2015-11-17 Laget: 2015-11-17 Sist oppdatert: 2015-11-19bibliografisk kontrollert
Inngår i avhandling
1. Synthesis and Applications of Dynamic Multivalent Nanostructures
Åpne denne publikasjonen i ny fane eller vindu >>Synthesis and Applications of Dynamic Multivalent Nanostructures
2015 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

This thesis focuses on the design, synthesis and development of dynamic multivalent nanostructures such as supramolecular dendrimers, liposomes and gold-functionalized nanostructures. These structures can be used for drug delivery and molecular sensing applications. This thesis is divided into three parts:

In part one, a general introduction to self-assembly, dynamic systems, metalligand exchange, nanostructured dendritic scaffolds, liposomes and gold nanostructures is given.

In part two, a microwave approach is presented as an efficient method for the regioselective deuteration of bipyridine scaffolds. Dynamic systems based on transition metal-bipyridine coordination complexes were investigated. The compositional self-adaptation and kinetics of these dynamic systems were successfully assessed by ESI-MS. Based on this amphiphilic dendrimers/metallodendrimers were also designed and synthesized via  a convergent strategy. Their ability to self-assemble into supramolecular assemblies and their controlled disassembly was effectively demonstrated.

In part three, two types of drug delivery systems based on dynamic multivalent nanostructures of glycodendrimers/metalloglycodendrimers and drugpresenting liposomes were developed. The dynamic self-assembly of these architectures into supramolecular nanostructures with site-specific functionality through interacting carbohydrate or cholesterol moieties was assessed. The host-guest interaction/encapsulation and controlled release with external stimuli were studied using a fluorescent probe, as well as selected drug molecules. The antibacterial property of the drug delivery systems was also evaluated, demonstrating an enhanced bactericidal activity. A new, rapid and simple approach for the functionalization of plasmonic gold nanostructured surfaces was also developed. The optical performance and light-specific sensitivity of the fluorescent probe on the resulting nanostructures were also presented.

sted, utgiver, år, opplag, sider
Stockholm: KTH Royal Institute of Technology, 2015. s. 80
Serie
TRITA-CHE-Report, ISSN 1654-1081 ; 2015:43
Emneord
multivalent nanostructures, self-assembly, metal-ligand exchange, dynamic covalent chemistry, bipyridine derivatives, dendrimers, liposomes, drug delivery, antimicrobial materials, fluorescent probe, plasmonic chemistry, gold surface functionalization
HSV kategori
Forskningsprogram
Kemi
Identifikatorer
urn:nbn:se:kth:diva-177280 (URN)978-91-7595-662-6 (ISBN)
Disputas
2015-12-11, F3, Lindstedtsvägen 26, KTH, Stockholm, 14:00 (engelsk)
Opponent
Veileder
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, KDHH B61632
Merknad

QC 20151119

Tilgjengelig fra: 2015-11-19 Laget: 2015-11-17 Sist oppdatert: 2015-11-19bibliografisk kontrollert

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