This presentation aims to share our experiences on the development of PROFILES with in-service science teachers for grade 7-9 in Sweden during the period of time from year 2012 to 2014. Inquiry-based science education (IBSE) has been addressed in science education internationally during the past decades, and the new Swedish curriculum from 2011 also emphasize the need to develop students’ inquiry skills. However, to what extent school teachers in Sweden have developed their professional knowledge on IBSE has only been focused in a small number of studies in Sweden and it was found that in-service teachers were not well-informed about the ideas of IBSE [1]. Therefore, in the PROFILES project in Sweden, we could create time and space for in-service teachers to develop and reflect on IBSE. During the two PROFILES teacher groups, as science education researchers and educators, we also develop our knowledge and skills on how to develop a successful teachers’ professional development [2].