Digitala Vetenskapliga Arkivet

Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
WRAP53 promotes cancer cell survival and is a potential target for cancer therapy
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Oto-Rhino-Laryngologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Oto-Rhino-Laryngologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Rekonstruktionscentrum, Öronkliniken US.
Karolinska Institute.
2011 (engelsk)Inngår i: CELL DEATH and DISEASE, ISSN 2041-4889, Vol. 2, nr e114Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

We previously identified WRAP53 as an antisense transcript that regulates the p53 tumor suppressor. The WRAP53 gene also encodes a protein essential for Cajal body formation and involved in cellular trafficking of the survival of motor neuron complex, the telomerase enzyme and small Cajal body-specific RNAs to Cajal bodies. Here, we show that the WRAP53 protein is overexpressed in a variety of cancer cell lines of different origin and that WRAP53 overexpression promotes cellular transformation. Knockdown of the WRAP53 protein triggers massive apoptosis through the mitochondrial pathway, as demonstrated by Bax/Bak activation, loss of mitochondrial membrane potential and cytochrome c release. The apoptosis induced by WRAP53 knockdown could moreover be blocked by Bcl-2 overexpression. Interestingly, human tumor cells are more sensitive to WRAP53 depletion as compared with normal human cells indicating that cancer cells in particular depends on WRAP53 expression for their survival. In agreement with this, we found that high levels of WRAP53 correlate with poor prognosis of head and neck cancer. Together these observations propose a role of WRAP53 in carcinogenesis and identify WRAP53 as a novel molecular target for a large fraction of malignancies.

sted, utgiver, år, opplag, sider
Nature Publishing Group , 2011. Vol. 2, nr e114
Emneord [en]
WRAP53, Wdr79, TCAB1, mitochondrial-dependent apoptosis, oncogene, head and neck cancer
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-65955DOI: 10.1038/cddis.2010.90ISI: 000286621400003OAI: oai:DiVA.org:liu-65955DiVA, id: diva2:400664
Tilgjengelig fra: 2011-02-28 Laget: 2011-02-28 Sist oppdatert: 2014-09-23

Open Access i DiVA

fulltext(808 kB)284 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 808 kBChecksum SHA-512
073d83deaed817cdb949c1b2df3f465d9d201b5f8c9cc3063e335e10b7c758957fa9d5741dedc05949ebc9bfe5b5b7647e195f5766b11b7a6b5a903dcceca954
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Søk i DiVA

Av forfatter/redaktør
Roberg, Karin
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 298 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 163 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf