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Pharmaceutical cocrystal and salts of norfloxacin
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Institutionen för tillämpad fysik och elektronik, Energiteknik och termisk processkemi.
2006 (engelsk)Inngår i: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 6, nr 12, s. 2699-2708Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this study was to investigate the structural and pharmaceutical properties of norfloxacin ( a poorly soluble antibacterial drug), its cocrystal, and salts. Norfloxacin in the anhydrous form ( form A, 1) was crystallized. It was cocrystallized with isonicotinamide ( 2), and organic salts were prepared with succinic acid, malonic acid, and maleic acid (3-5, respectively). These phases were characterized by differential scanning calorimetry (DSC), infrared (IR) and Raman spectroscopy, and powder X-ray diffraction (PXRD). Single-crystal X-ray diffraction data were obtained, and crystal structures were solved. The apparent solubility of these phases was determined. Robust O-H center dot center dot center dot O, O-H center dot center dot center dot O-, O-H center dot center dot center dot N, N-H center dot center dot center dot O, N+- H center dot center dot center dot O-, and N-H center dot center dot center dot N interactions were present in all these structures. Quinolone moieties in these structures stack with pi...pi interactions and form channels to include CHCl3 or H2O. Herein we report a new cocrystal and salts of norfloxacin with improved aqueous solubility.

sted, utgiver, år, opplag, sider
American Chemical Society , 2006. Vol. 6, nr 12, s. 2699-2708
Identifikatorer
URN: urn:nbn:se:umu:diva-38609DOI: 10.1021/cg060327xISI: 000242575100016OAI: oai:DiVA.org:umu-38609DiVA, id: diva2:379676
Tilgjengelig fra: 2010-12-19 Laget: 2010-12-19 Sist oppdatert: 2018-06-08bibliografisk kontrollert

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