Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Molecular characterization of cholinergic vestibular and olivocochlear efferent neurons in the rodent brainstem.
Linköpings universitet, Institutionen för fysik, kemi och biologi.
2010 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 40 poäng / 60 hpOppgave
Abstract [en]

The neural code from the inner ear to the brain is dynamically controlled by central nervous efferent feedback to the audio-vestibular epithelium. Although such efference provides the basis for a cognitive control of our hearing and balance, we know surprisingly little about this feedback system. This project has investigated the applicability of a transgenic mouse model, expressing a fluorescent protein under the choline-acetyltransferase (ChAT) promoter, for targeting the cholinergic audio-vestibular efferent neurons in the brainstem. It was found that the mouse model is useful for targeting the vestibular efferents, which are fluorescent, but not the auditory efferents, which are not highlighted. This model enables, for the first time, physiological studies of the vestibular efferent neurons and their synaptic inputs. We next assessed the expression of the potassium channel family Kv4, known to generate transient potassium currents upon depolarization. Such potassium currents are found in auditory efferent neurons, but it is not known whether Kv4 subunits are expressed in these neurons. Moreover, it is not known if Kv4 is present and has a function in the vestibular efferent neurons. Double labelling with anti-ChAT and anti-Kv4.2 or Kv4.3 demonstrates that the Kv4.3 subunits are abundantly expressed in audio-vestibular efferents, thus indicating that this subunit is a large contributor to the excitability and firing properties of the auditory efferent neurons, and most probably also for the vestibular efferent neurons. In addition, we also unexpectedly found a strong expression of Kv4.3 in principal cells of the superior olive, the neurons which are important for sound localization.

sted, utgiver, år, opplag, sider
2010. , s. 28
Emneord [en]
Vestibular efferents, olivocochlear efferents, principal cells, GFP, ChAT, superior olivary complex, Kv4.3, transient outward current, A-type current
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-56844ISRN: LITH-IFM-A-Ex--10/2319--SEOAI: oai:DiVA.org:liu-56844DiVA, id: diva2:322541
Uppsök
Medicine
Veileder
Examiner
Tilgjengelig fra: 2010-06-09 Laget: 2010-06-07 Sist oppdatert: 2018-01-12bibliografisk kontrollert

Open Access i DiVA

fulltekst(1282 kB)659 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 1282 kBChecksum SHA-512
f8dc2ca00d1c9ec3865195e1df3b4422fb5ab3e236f1ca81640125485a3308ae9f37df016df5eda2c36f0e8553219de531ced815b55187d17fb121ebe1498357
Type fulltextMimetype application/pdf

Søk i DiVA

Av forfatter/redaktør
Leijon, Sara
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 659 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

urn-nbn

Altmetric

urn-nbn
Totalt: 161 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf