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Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk mikrobiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk mikrobiologi.
Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Onkologiska kliniken US. (Landstinget i Östergötland)
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
2006 (engelsk)Inngår i: FEMS Immunology and Medical Microbiology, ISSN 0928-8244, E-ISSN 1574-695X, Vol. 47, nr 2, s. 207-216Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Atherosclerosis and coronary heart disease are causing high morbidity and mortality worldwide. Different risk factors have been demonstrated, but the exact mechanisms behind these diseases are still not fully understood. Recent studies have suggested Chlamydia pneumoniae to be involved in the pathogenesis, and increased apoptotic indexes in atherosclerotic plaques have been documented. In this study, we show that C. pneumoniae induces apoptosis and necrosis in populations of human coronary artery endothelial cells. Apoptosis was determined by TUNEL and flow cytometry after staining of cells with annexin V and propidium iodide, and defined as TUNEL-reactive or annexin V-positive, propidium iodide-negative cells. The apoptosis was induced within 2 h postinfection and increased with inoculation dose. The general caspase inhibitor z-VAD-fmk did not affect apoptotic frequencies. By immunochemistry and immunoblot, we demonstrated activation and subcellular translocation of the proapoptotic protein Bax, and translocation of apoptosis-inducing factor from the cytosol to the nucleus. These results indicate that C. pneumoniae-induced apoptosis in human coronary artery endothelial cells is caspase-independent and regulated by Bax and apoptosis-inducing factor.

sted, utgiver, år, opplag, sider
2006. Vol. 47, nr 2, s. 207-216
Emneord [en]
Chlamydia pneumoniae, coronary cells, apoptosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-17128DOI: 10.1111/j.1574-695X.2006.00083.xPubMedID: 16831207OAI: oai:DiVA.org:liu-17128DiVA, id: diva2:202104
Merknad
The definitive version is available at www.blackwell-synergy.com:Johan Schöier, Marie Högdahl, Gustaf Söderlund and Erik Kihlström, Chlamydia (Chlamydophila) pneumoniae-induced cell death in human coronary artery endothelial cells is caspase-independent and accompanied by subcellular translocations of Bax and apoptosis-inducing factor., 2006, FEMS Immunology and Medical Microbiology, (47), 2, 207-216.http://dx.doi.org/10.1111/j.1574-695X.2006.00083.xCopyright: Blackwell Publishing Ltd. http://www.blackwellpublishing.com/and Scandinavian Societies for Medical Microbiology and PathologyTilgjengelig fra: 2009-03-07 Laget: 2009-03-06 Sist oppdatert: 2017-12-13bibliografisk kontrollert

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