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Iodine Supplemented Diet Positively Affect Immune Response and Dairy Product Quality in Fresian Cow
Univ Teramo, Fac Biosci & Technol Food Agr & Environm, Via R Balzarini 1, I-64100 Teramo, Italy.
G dAnnunzio Univ Chieti Pescara, Dept Med Oral & Biotechnol Sci, Via Vestini 31, I-66100 Chieti, Italy.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Neuroonkologi.ORCID-id: 0000-0002-2592-3448
Ist Zooprofilatt Sperimentale Abruzzo & Molise G, Via Campo Boario, I-64100 Teramo, Italy.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Animals, ISSN 2076-2615, E-ISSN 2076-2615, Vol. 9, nr 11, artikkel-id 866Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Simple Summary: Iodine represents an important micronutrient and plays a fundamental role in animal biology. This trace element is currently supplied to animal diet to investigate its potential effects on productive and reproductive performances. However, little is known about its role in the regulation of gene expression in ruminants. In this study, the dietary iodine supplementation in dairy cows showed effective modification of the expression of several molecular targets, with an improvement of the pathways involved in immune response and oxidative stress and undoubted positive repercussions on animal health. Abstract: The effects of iodine supplementation on the whole-transcriptome of dairy cow using RNA sequencing has been investigated in this study. Iodine did not influence the milk composition, while an improvement was observed in the immune response as well as in the quality of dairy product. Indeed, the iodine intake specifically influenced the expression of 525 genes and the pathway analysis demonstrated that the most affected among them were related to immune response and oxidative stress. As a consequence, we indirectly showed a better response to bacterial infection because of the reduction of somatic cell counts; furthermore, an improvement of dairy product quality was observed since lipid oxidation reduced in fresh cheese. Such findings, together with the higher milk iodine content, clearly demonstrated that iodine supplementation in dairy cow could represent a beneficial practice to preserve animal health and to improve the nutraceutical properties of milk and its derived products.

sted, utgiver, år, opplag, sider
MDPI , 2019. Vol. 9, nr 11, artikkel-id 866
Emneord [en]
Iodine, immune response, oxidative stress, somatic cell count, fresh cheese, transcriptomics
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-400823DOI: 10.3390/ani9110866ISI: 000502299900012PubMedID: 31731565OAI: oai:DiVA.org:uu-400823DiVA, id: diva2:1384934
Tilgjengelig fra: 2020-01-13 Laget: 2020-01-13 Sist oppdatert: 2020-01-13bibliografisk kontrollert

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