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Proteomic Analysis of Longitudinal Changes in Blood Pressure
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi. Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan.ORCID-id: 0000-0002-5833-0040
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Kardiologi.ORCID-id: 0000-0003-2071-5866
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Molekylär epidemiologi.ORCID-id: 0000-0001-5894-0351
Vise andre og tillknytning
2019 (engelsk)Inngår i: JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, Vol. 8, nr 10, artikkel-id 1585Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmo Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts.

sted, utgiver, år, opplag, sider
MDPI, 2019. Vol. 8, nr 10, artikkel-id 1585
Emneord [en]
proteomics, blood pressure, hypertension, prospective cohort
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-400097DOI: 10.3390/jcm8101585ISI: 000498398500083PubMedID: 31581667OAI: oai:DiVA.org:uu-400097DiVA, id: diva2:1383194
Forskningsfinansiär
Swedish Heart Lung Foundation, 20041151Tilgjengelig fra: 2020-01-07 Laget: 2020-01-07 Sist oppdatert: 2020-01-07bibliografisk kontrollert

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