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Current and Future Approaches for Monitoring Responses to Anti-complement Therapeutics
Univ Penn, Dept Surg, Div Transplantat, Philadelphia, PA 19104 USA.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Klinisk immunologi.
Linnaeus Univ, Ctr Biomat Chem, Kalmar, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Frontiers in Immunology, ISSN 1664-3224, E-ISSN 1664-3224, Vol. 10, artikkel-id 2539Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Aberrations in complement system functions have been identified as either direct or indirect pathophysiological mechanisms in many diseases and pathological conditions, such as infections, autoimmune diseases, inflammation, malignancies, and allogeneic transplantation. Currently available techniques to study complement include quantification of (a) individual complement components, (b) complement activation products, and (c) molecular mechanisms/function. An emerging area of major interest in translational studies aims to study and monitor patients on complement regulatory drugs for efficacy as well as adverse events. This area is progressing rapidly with several anti-complement therapeutics under development, in clinical trials, or already in clinical use. In this review, we summarized the appropriate indications, techniques, and interpretations of basic complement analyses, exemplified by a number of clinical disorders.

sted, utgiver, år, opplag, sider
2019. Vol. 10, artikkel-id 2539
Emneord [en]
clinical trial, laboratory investigation, immunoassays, functional assays, CV%
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-398795DOI: 10.3389/fimmu.2019.02539ISI: 000498927000001PubMedID: 31787968OAI: oai:DiVA.org:uu-398795DiVA, id: diva2:1377287
Forskningsfinansiär
Swedish Research Council, 2015-06429Swedish Research Council, 2016-2075-5.1Swedish Research Council, 2016-04519
Merknad

Maedeh Mohebnasab and Oskar Eriksson are joint first authors.

Tilgjengelig fra: 2019-12-11 Laget: 2019-12-11 Sist oppdatert: 2020-01-08bibliografisk kontrollert

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