Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations
Vise andre og tillknytning
2019 (engelsk)Inngår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, nr 8, artikkel-id 1954Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the VDR, GC, and CYP27B1 genes. We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). However, none of these SNPs were statistically significant after Benjamini-Hochberg (BH) multiple testing correction. When assessed by a priori defined functional pathways, tumor growth factor beta (TGF beta) signaling was associated with CRC risk (P <= 0.001), with most statistically significant genes being SMAD7 (P-BH = 0.008) and SMAD3 (P-BH = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (P = 0.036). The 25(OH)D-gene pathway analysis suggested that genetic variants in the genes related to VDR complex formation and transcriptional activity are associated with CRC depending on 25(OH)D levels (interaction P = 0.041). Additional studies in large populations and consortia, especially with measured circulating 25(OH)D, are needed to confirm our findings.

sted, utgiver, år, opplag, sider
MDPI, 2019. Vol. 11, nr 8, artikkel-id 1954
Emneord [en]
single nucleotide polymorphism (SNP), vitamin D, colorectal neoplasms, incidence
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-164430DOI: 10.3390/nu11081954ISI: 000484506000154PubMedID: 31434255OAI: oai:DiVA.org:umu-164430DiVA, id: diva2:1362982
Tilgjengelig fra: 2019-10-22 Laget: 2019-10-22 Sist oppdatert: 2019-10-22bibliografisk kontrollert

Open Access i DiVA

fulltext(437 kB)17 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 437 kBChecksum SHA-512
e74655b4790f05defbd50558bf9f3a7c43ab352522a8af1d30298391da570c156fcda89f576a7e5e9d8abbc1a42ee5e8b1194e3c0d1889208bcb964376ccd6a6
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Søk i DiVA

Av forfatter/redaktør
Perduca, VittorioGylling, BjörnHarlid, Sophia
Av organisasjonen
I samme tidsskrift
Nutrients

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 17 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 42 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf