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Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein-protein interfaces of nuclear factors
Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.
Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.
Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.
Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.
2017 (engelsk)Inngår i: British Journal of Pharmacology, ISSN 0007-1188, E-ISSN 1476-5381, Vol. 174, nr 24, s. 4600-4610Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Mutations in components of the Wnt pathways are a frequent cause of many human diseases, particularly cancer. Despite the fact that a causative link between aberrant Wnt signalling and many types of human cancers was established more than a decade ago, no Wnt signalling inhibitors have made it into the clinic so far. One reason for this is that no pathway-specific kinase is known. Additionally, targeting the protein-protein interactions needed to transduce the signal has not met with success so far. Complicating the search for and use of inhibitors is the complexity of the cascades triggered by the Wnts and their paramount biological importance. Wnt/β-catenin signalling is involved in virtually all aspects of embryonic development and in the control of the homeostasis of adult tissues. Encouragingly, however, in recent years, first successes with Wnt-pathway inhibitors have been reported in mouse models of disease. In this review, we summarize possible roads to follow during the quest to pharmacologically modulate the Wnt signalling pathway in cancer.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2017. Vol. 174, nr 24, s. 4600-4610
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Identifikatorer
URN: urn:nbn:se:liu:diva-150048DOI: 10.1111/bph.13864ISI: 000427839000006PubMedID: 28521071Scopus ID: 2-s2.0-85020943692OAI: oai:DiVA.org:liu-150048DiVA, id: diva2:1237365
Tilgjengelig fra: 2018-08-08 Laget: 2018-08-08 Sist oppdatert: 2018-08-22bibliografisk kontrollert

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