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Cytotoxic quinones from the roots of Aloe dawei.
Vise andre og tillknytning
2014 (engelsk)Inngår i: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 19, nr 3, s. 3264-3273Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC₅₀ 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.

sted, utgiver, år, opplag, sider
2014. Vol. 19, nr 3, s. 3264-3273
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URN: urn:nbn:se:uu:diva-356010DOI: 10.3390/molecules19033264PubMedID: 24642911OAI: oai:DiVA.org:uu-356010DiVA, id: diva2:1232398
Tilgjengelig fra: 2018-07-11 Laget: 2018-07-11 Sist oppdatert: 2018-07-11

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