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Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Transplantation och regenerativ medicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Transplantation och regenerativ medicin. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk cellbiologi.ORCID-id: 0000-0001-8843-7941
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Transplantationskirurgi.ORCID-id: 0000-0003-0238-0839
Vise andre og tillknytning
2018 (engelsk)Inngår i: American Journal of Transplantation, ISSN 1600-6135, E-ISSN 1600-6143, Vol. 18, nr 7, s. 1735-1744Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Macroencapsulation devices provide the dual possibility to immunoprotect transplanted cells while also being retrievable; the latter bearing importance for safety in future trials with stem-cell derived cells. However, macroencapsulation entails a problem with oxygen supply to the encapsulated cells. The βAir device solves this with an incorporated refillable oxygen tank. This phase 1 study evaluated the safety and efficacy of implanting the βAir device containing allogeneic human pancreatic islets to patients with type 1 diabetes. Four patients were transplanted with 1-2 βAir devices, each containing 155000-180000 IEQ (i.e. 1800-4600 IEQ per kg body weight), and monitored for 3-6 months, followed by the recovery of devices. Implantation of the βAir device was safe and successfully prevented immunization and rejection of the transplanted tissue. However, although beta cells survived in the device, only minute levels of circulating C-peptide were observed with no impact on metabolic control. Fibrotic tissue with immune cells was formed in capsule surroundings. Recovered devices displayed a blunted glucose-stimulated insulin response, and amyloid formation in the endocrine tissue. We conclude that the βAir device is safe and can support survival of allogeneic islets for several months, although the function of the transplanted cells was limited.

sted, utgiver, år, opplag, sider
2018. Vol. 18, nr 7, s. 1735-1744
Emneord [en]
cellular biology, clinical research, practice, diabetes: type 1, encapsulation, endocrinology, diabetology, islet transplantation, islets of Langerhans, translational research, science
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-337701DOI: 10.1111/ajt.14642ISI: 000437727800020PubMedID: 29288549OAI: oai:DiVA.org:uu-337701DiVA, id: diva2:1170569
Forskningsfinansiär
Ernfors FoundationSwedish Diabetes AssociationSwedish Research Council, 921-2014-7054Swedish Research Council, K2013-55X-15043Swedish Research Council, K2015-54X-12219-19-4Swedish Research Council, K2016-01040Swedish Research Council, K2016-GTWNovo NordiskSwedish Child Diabetes FoundationEU, European Research Council, F4-2013-602889EU, European Research Council, 646075-ELASTISLETEXODIAB - Excellence of Diabetes Research in Sweden
Merknad

De två första författarna delar förstaförfattarskapet.

Tilgjengelig fra: 2018-01-03 Laget: 2018-01-03 Sist oppdatert: 2019-07-03bibliografisk kontrollert

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Carlsson, Per-OlaEspes, DanielSedigh, AmirWestermark, Gunilla T.Carlbom, LinaAhlström, HåkanEriksson, OlofOlerud, JohanKorsgren, Olle
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