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Estimation and interpretation of genetic effects with epistasis using the NOIA model
Dalarna University, School of Technology and Business Studies, Statistics.ORCID iD: 0000-0002-1057-5401
2012 (English)In: Quantitative trait loci (QTL): Methods and Protocols / [ed] Scott A. Rifkin, Humana Press, 2012, 191-204 p.Chapter in book (Other academic)
Abstract [en]

We introduce this communication with a brief outline of the historical landmarks in genetic modeling, especially concerning epistasis. Then, we present methods for the use of genetic modeling in QTL analyses. In particular, we summarize the essential expressions of the natural and orthogonal interactions (NOIA) model of genetic effects. Our motivation for reviewing that theory here is twofold. First, this review presents a digest of the expressions for the application of the NOIA model, which are often mixed with intermediate and additional formulae in the original articles. Second, we make the required theory handy for the reader to relate the genetic concepts to the particular mathematical expressions underlying them. We illustrate those relations by providing graphical interpretations and a diagram summarizing the key features for applying genetic modeling with epistasis in comprehensive QTL analyses. Finally, we briefly review some examples of the application of NOIA to real data and the way it improves the interpretability of the results.

Place, publisher, year, edition, pages
Humana Press, 2012. 191-204 p.
Series
Methods in Molecular Biology, ISSN 1064-3745 ; 871
National Category
Genetics
Research subject
Komplexa system - mikrodataanalys, General Microdata Analysis - methods
Identifiers
URN: urn:nbn:se:du-10108DOI: 10.1007/978-1-61779-785-9_10ISBN: 978-1-61779-784-2 (print)OAI: oai:DiVA.org:du-10108DiVA: diva2:528100
Available from: 2012-05-24 Created: 2012-05-24 Last updated: 2015-06-08Bibliographically approved

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CiteExportLink to record
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Cite
Citation style
  • apa
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Language
  • de-DE
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  • nn-NB
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