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Postglacial Population History of the Common Shrew (Sorex araneus) in Fennoscandia: Molekylära studier av återkolonisation, könsbundet genflöde och kromosomrasbildning.
Uppsala University, Teknisk-naturvetenskapliga vetenskapsområdet, Faculty of Science and Technology, Biology, Department of Ecology and Evolution, Conservation Biology and Genetics.
2004 (English)Doctoral thesis, comprehensive summary (Other academic)Alternative title
Den vanliga näbbmusens (Sorex araneus) postglaciala populationshistoria i Fennoskandien : Molekylära studier av återkolonisation, könsbundet genflöde och kromosomrasbildning. (Swedish)
Abstract [en]

The common shrew, Sorex araneus, has one of the most variable karyotypes among mammals, displaying numerous chromosomes races throughout its distribution, which can be categorized into different karyotypic groups. The objective of this thesis was to examine the postglacial population history of Fennoscandian common shrews using autosomal microsatellites, mitochondrial DNA (mtDNA) and a Y chromosome specific microsatellite (L8Y).

Autosomal microsatellites and mtDNA revealed weak genetic structure over a hybrid zone between the karyotypically divergent Northern and Western karyotypic groups. However, the genetic structure displayed by the Y chromosome microsatellite was orders of magnitude higher. Hence, considerable chromosomal differences between the groups do not prevent female gene flow, while male gene flow is reduced (cf. Haldane's rule). Further, the results suggest that the Haldane effect may be caused by the chromosomal differences between the karyotypic groups.

No mtDNA differentiation was observed either between chromosome races or between the Northern and Western karyotypic groups in Fennoscandia. The combined pattern of karyotypic and mtDNA variation of Fennoscandian common shrews, suggest bi-directional postglacial recolonisation from a single refugium in Europe. The variation of the Y-linked microsatellite supported this conclusion. In contrast, significant mtDNA structure, discordant with the karyotypic variation, revealed that common shrews in southern Finland belong to a different lineage than remaining Fennoscandian regions, implying postglacial recolonisation from a different source.

MtDNA variation of the chromosome races in Sweden supports the hypothesis that three races of the Western karyotypic group have been formed through whole arm reciprocal translocations (WARTs), as suggested by their mutual karyotypic variation. The variation of the molecular markers supports the theory of rapid karyotypic evolution in the common shrew.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis , 2004. , 56 p.
Series
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 986
Keyword [en]
Molecular genetics, Sorex araneus, chromosome race, postglacial recolonisation, hybrid zone, sex-biased gene flow, chromosomal evolution
Keyword [sv]
Genetik
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-4289ISBN: 91-554-5986-2 (print)OAI: oai:DiVA.org:uu-4289DiVA: diva2:164718
Public defence
2004-06-04, Zootissalen, EBC, Uppsala, 10:00
Opponent
Supervisors
Available from: 2004-05-13 Created: 2004-05-13Bibliographically approved
List of papers
1. No apparent reduction of gene flow in a hybrid zone between the West and North European karyotypic groups of the common shrew, Sorex araneus.
Open this publication in new window or tab >>No apparent reduction of gene flow in a hybrid zone between the West and North European karyotypic groups of the common shrew, Sorex araneus.
2004 In: Molecular Ecology, ISSN 1365-294X, Vol. 13, no 5, 1205-1215. p.Article in journal (Refereed) Published
Identifiers
urn:nbn:se:uu:diva-91849 (URN)
Available from: 2004-05-13 Created: 2004-05-13Bibliographically approved
2. Lack of mitochondrial DNA structure between chromosome races of the common shrew, Sorex araneus, in Sweden. Implications for chromosomal evolution.
Open this publication in new window or tab >>Lack of mitochondrial DNA structure between chromosome races of the common shrew, Sorex araneus, in Sweden. Implications for chromosomal evolution.
Manuscript (Other academic)
Identifiers
urn:nbn:se:uu:diva-91850 (URN)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2010-01-13Bibliographically approved
3. Fennoscandian phylogeography of the common shrew Sorex araneus. Postglacial recolonisation-combining information from chromosomal variation with mitochondrial DNA data
Open this publication in new window or tab >>Fennoscandian phylogeography of the common shrew Sorex araneus. Postglacial recolonisation-combining information from chromosomal variation with mitochondrial DNA data
2011 (English)In: Acta Theriologica, ISSN 0001-7051, Vol. 56, no 2, 103-116 p.Article in journal (Refereed) Published
Abstract [en]

We examine mtDNA variation of the common shrew in Fennoscandia to explore the incongruence found in previous studies using chromosomal and mitochondrial markers, aiming to reveal post-glacial recolonisation patterns. A total of 241 common shrews from 51 localities in Fennoscandia were analysed. This area includes a secondary contact zone between two groups (the Northern group and the Western group) showing distinct karyotypes. All individuals were sequenced for 447 bp of the mitochondrial control region. No significant differentiation in the mtDNA variation was observed between the two major chromosomal groups in Fennoscandia. The star-like shape of the sequence network for the entire study area shows the most common haplotype A as ancestral in all regions but one, in situ formation of most haplotypes and population expansion. The only significant mtDNA structure observed occurs between south Finland and the rest of Fennoscandia. We propose that the Northern and Western group shared a common refugium during the Last Glacial Maximum but recolonised Fennoscandia via two routes. Karyotypic differences between south and north Finland has led researchers to suggest that both regions originate from the same ancestral population east of Finland. The observed divergence of mtDNA variation between these two regions supports this hypothesis.

Keyword
Control region, Common shrew, Glacial refugia, Colonization history, Chromosome race
National Category
Biological Sciences
Identifiers
urn:nbn:se:uu:diva-91851 (URN)10.1007/s13364-010-0022-9 (DOI)000290689600001 ()
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2014-01-08Bibliographically approved
4. Reduced levels of male gene flow in a hybrid zone between the North and West European karyotypic groups of the common shrew, Sorex araneus. Chromosomally based explanation for Haldane's rule?
Open this publication in new window or tab >>Reduced levels of male gene flow in a hybrid zone between the North and West European karyotypic groups of the common shrew, Sorex araneus. Chromosomally based explanation for Haldane's rule?
Manuscript (Other academic)
Identifiers
urn:nbn:se:uu:diva-91852 (URN)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2010-01-13Bibliographically approved
5. Y-chromosome microsatellite variation among common shrews (Sorex araneus) in northern Europe.
Open this publication in new window or tab >>Y-chromosome microsatellite variation among common shrews (Sorex araneus) in northern Europe.
Manuscript (Other academic)
Identifiers
urn:nbn:se:uu:diva-91853 (URN)
Available from: 2004-05-13 Created: 2004-05-13 Last updated: 2010-01-13Bibliographically approved

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