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Negative frequency dependent selection on sympatric mtDNA haplotypes in Drosophila subobscura
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.ORCID iD: 0000-0002-3501-3376
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology. Univ Belgrade, Inst Biol Res Sinisa Stankovic, Despot Stefan Blvd 142, Belgrade 11000, Serbia..
Univ Illes Balears, Fac Ciencies, Dept Biol, Lab Genet, Edifici Guillem Colom,Campus UIB, Palma de Mallorca 07122, Balears, Spain..
Uppsala University, Disciplinary Domain of Science and Technology, Biology, Department of Ecology and Genetics, Animal ecology.
2016 (English)In: Hereditas, ISSN 0018-0661, E-ISSN 1601-5223, Vol. 153, 15Article in journal (Refereed) Published
Abstract [en]

Background: Recent experimental evidence for selection on mitochondrial DNA (mtDNA) has prompted the question as to what processes act to maintain within-population variation in mtDNA. Balancing selection though negative frequency dependent selection (NFDS) among sympatric haplotypes is a possibility, but direct empirical evidence for this is very scarce. Findings: We extend the previous findings of a multi-generation replicated cage experiment in Drosophila subobscura, where mtDNA polymorphism was maintained in a laboratory setting. First, we use a set of Monte Carlo simulations to show that the haplotype frequency dynamics observed are inconsistent with genetic drift alone and most closely match those expected under NFDS. Second, we show that haplotype frequency changes over time were significantly different from those expected under either genetic drift or positive selection but were consistent with those expected under NFSD. Conclusions: Collectively, our analyses provide novel support for NFDS on mtDNA haplotypes, suggesting that mtDNA polymorphism may at least in part be maintained by balancing selection also in natural populations. We very briefly discuss the possible mechanisms that might be involved.

Place, publisher, year, edition, pages
2016. Vol. 153, 15
Keyword [en]
Balancing selection, mtDNA, Life history evolution, Polymorphism, Negative frequency dependent selection, SimuPop
National Category
Genetics
Identifiers
URN: urn:nbn:se:uu:diva-315926DOI: 10.1186/s41065-016-0020-2ISI: 000391695500001PubMedID: 28096777OAI: oai:DiVA.org:uu-315926DiVA: diva2:1076519
Funder
EU, European Research Council, GENCON AdG-294333Swedish Research Council, 621-2014-4523
Available from: 2017-02-23 Created: 2017-02-23 Last updated: 2017-02-23Bibliographically approved

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