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Developing Glycopeptide based nanocarriers by ring opening polymerization for drug delivery applications
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström. (Polymer Chemistry)
2014 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
Abstract [en]

Synthetic glycopeptides have attracted much interest in the biomedical field due to their structural similarities to the natural glycopeptides or glycoproteins. It is still difficult to synthesize glycopeptides with greater efficiency and ring opening polymerization remains an effective way to do so. Proteoglycans are a special class of glycoproteins with glycosaminoglycan chains. In this study, I tried to do controlled ring opening polymerization of Hyaluronic acid derivatives with smaller to higher molecular weight while avoiding side reactions. It is challenging to work with higher molecular weight molecules and do a click reaction in water effectively. Making nanopolymers with a desired size, studies of the characteristics, and how to build nanocarriers for drug delivery application was the focus of this work. Polymeric characteristics, e.g., modification and polymer formation were studied by nuclear magnetic resonance technique; Particle size was studied by dynamic light scattering and the loading of rhodamine B encapsulated into the polymer was measured by confocal imaging technique.

sted, utgiver, år, opplag, sider
2014. , s. 32
Serie
UPKEM E ; 26
Emneord [en]
Ring opening polymerization, N-Carboxyanhydride, Glycopeptide, Hyaluronic acid, Glycoseaminoglycan, Polymeric nanoparticle, Cancer treatment.
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-233891OAI: oai:DiVA.org:uu-233891DiVA, id: diva2:754807
Fag / kurs
Chemistry
Utdanningsprogram
Master Programme in Chemistry
Veileder
Examiner
Tilgjengelig fra: 2014-10-14 Laget: 2014-10-13 Sist oppdatert: 2014-10-14bibliografisk kontrollert

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Master Thesis of Mohammad Nazmul Hasan(1647 kB)576 nedlastinger
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