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Synthesis of multicyclic 2-pyridones from a formyl and chlorometylene substituted precursor using a strategy of directed diversity-oriented synthesis
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
2012 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 30 poäng / 45 hpOppgave
Abstract [en]

Multi ring-fused 2-pyridones have shown interesting activity in a variety of biological systems. It would be of great interest to explore the biological application of even more multi heterocyclic ring fused 2-pyridones. ‘Diversity oriented synthesis’ is an excellent concept emerged in recent years to access compounds with structurally and stereochemically diverse skeletons. This served as an efficient avenue for synthesizing various ring fused 2-pyridones using formyl, chloromethylene substituted 2-pyridone (

6) as a starting compound. By treating the starting material (6) with various nucleopliles, different sized heterocyclic ring fused 2-pyridones has been synthesized. Additionally, an improved methodology for the synthesis of naphthyridones was presented.

sted, utgiver, år, opplag, sider
2012. , s. 23
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-56763OAI: oai:DiVA.org:umu-56763DiVA, id: diva2:537415
Utdanningsprogram
Master’s program in Chemistry
Uppsök
Physics, Chemistry, Mathematics
Veileder
Examiner
Tilgjengelig fra: 2012-06-26 Laget: 2012-06-26 Sist oppdatert: 2012-06-26bibliografisk kontrollert

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