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Micro Scale Synthesis of Tritium LabeledIsoallopregnanolone for Use in RIA-analysis
Umeå universitet, Teknisk-naturvetenskapliga fakulteten, Kemiska institutionen.
2010 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 20 poäng / 30 hpOppgave
Abstract [en]

In this thesis it was shown that Isoallopregnanolone can be synthesized from

Allopregnanolone by the Mitsunobu reaction as well as by oxidation with o-iodoxybenzoic

acid (IBX) with subsequent reduction with NaBH

4. It was shown that the oxidation with

subsequent reduction was a better method for synthesis in microgram scale. The oxidationreduction

method was carried out in microgram scale on tritium labeled Allopregnanolone

(Pregnane-3α-ol-20one, 5α[9,11,12-

3H(N)] to produce the corresponding tritium labeled

Isoallopregnanolone. The possibility of synthesizing Tetrahydrodeoxycorticosterone

(THDOC) from Allopregnanolone in microgram scale was examined. Formation of a

silylenol ether analog of Allopregnanolone and subsequent oxidation with m-CPBA was

examined as a method to synthesizing THDOC. The synthesis of THDOC by this procedure

was found not to be efficient enough to be used in microgram scale

sted, utgiver, år, opplag, sider
2010. , s. 59
HSV kategori
Identifikatorer
URN: urn:nbn:se:umu:diva-56578OAI: oai:DiVA.org:umu-56578DiVA: diva2:535857
Uppsök
Physics, Chemistry, Mathematics
Veileder
Examiner
Tilgjengelig fra: 2012-06-21 Laget: 2012-06-20 Sist oppdatert: 2012-06-21bibliografisk kontrollert

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