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Synthesis of Structures Related to Antifreeze Glycoproteins
Linköpings universitet, Institutionen för fysik, kemi och biologi.
2005 (Engelska)Independent thesis Advanced level (degree of Magister), 20 poäng / 30 hpOppgave
Abstract [en]

In this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthalimido-β-D-1-thio-glucopyranoside, using silver triflate activation. Subsequent epimerization to a Gal-GalN disaccharide was achieved using Moffatt oxidation followed by L-selectride® reduction. The tripeptide was synthesized in a short and convenient manner using solid phase peptide synthesis with immobilized Fmoc-Ala on Wang® resins as starting point.

sted, utgiver, år, opplag, sider
Institutionen för fysik, kemi och biologi , 2005. , s. 49
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-11941ISRN: LITH-IFM-EX--05/1416--SEOAI: oai:DiVA.org:liu-11941DiVA: diva2:18342
Presentation
2005-06-03
Uppsök
fysik/kemi/matematik
Veileder
Examiner
Tilgjengelig fra: 2008-05-28 Laget: 2008-05-28

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